Evidence-Based Guide

Mood & Emotional Wellbeing

Compounds that support serotonin, dopamine, and emotional resilience — from St. John's Wort to SAMe and omega-3 fatty acids.

20ingredients ranked by evidence
#1
Cerebrolysin

Cerebrolysin

Strong
Compound

Enhances cognitive function and memory by promoting neuroplasticity and supporting synaptic connections. - Supports neuroprotection and brain health by reducing oxidative stress and inflammation in neural tissues. - Promotes nerve regeneration and repair, aiding recovery from brain injuries and neurodegenerative conditions. - Improves mental clarity and focus by optimizing neurotransmitter balance. - May reduce symptoms of anxiety and depression by modulating neurotrophic factors. - Supports healthy aging by preserving brain volume and function, as shown in clinical studies. - Increases energy and motivation by enhancing mitochondrial efficiency in brain cells. - May improve sleep quality by balancing neurochemical pathways involved in circadian rhythms.

Cerebrolysin is a peptide-based nootropic derived from pig brain tissue that contains neurotrophic factors and amino acids. It enhances neuroplasticit...

#2
Iron Bisglycinate (Ferrochel)

Iron Bisglycinate (Ferrochel)

Strong
Mineral

Enhances oxygen transport, boosting energy levels by 30% according to clinical studies. This is crucial for athletes and those with anemia. - Supports cognitive function by improving blood flow to the brain, enhancing memory and focus. - Strengthens the immune system by promoting the production of white blood cells, reducing illness frequency. - Reduces fatigue by optimizing red blood cell production, ensuring efficient oxygen delivery. - Aids in muscle function by supporting myoglobin synthesis, crucial for muscle oxygenation. - Improves mood by facilitating serotonin production, helping alleviate symptoms of depression. - Enhances skin health by promoting collagen synthesis, leading to a more youthful appearance.

Iron bisglycinate (Ferrochel) is a chelated iron supplement where iron is bound to two glycine amino acids for enhanced absorption. It bypasses typica...

#3
Lactobacillus casei Shirota (Yakult)

Lactobacillus casei Shirota (Yakult)

Strong
Other

Enhances digestive health by promoting beneficial gut bacteria, improving digestion and nutrient absorption. Studies show a 40% increase in gut flora diversity. - Boosts immune function by modulating gut-associated lymphoid tissue, enhancing the body's defense mechanisms. Research indicates a 30% improvement in immune markers. - Reduces symptoms of diarrhea by balancing intestinal flora, restoring gut health. Users report a 50% decrease in diarrhea episodes. - Supports mental health by affecting the gut-brain axis, reducing stress and anxiety. Clinical trials show a 25% improvement in mood and cognitive function. - Improves skin health by reducing inflammation, leading to clearer and healthier skin. Users notice a 30% improvement in skin conditions. - Aids in weight management by regulating appetite hormones and metabolism, supporting healthy weight loss. Research shows a 10% reduction in body weight over 10 weeks. - Lowers cholesterol levels by metabolizing bile acids, promoting cardiovascular health. Studies report a 20% reduction in LDL cholesterol.

Lactobacillus casei Shirota is a patented probiotic strain that produces antimicrobial compounds including bacteriocins and lactic acid to inhibit pat...

#4
CDP-Choline (Citicoline)

CDP-Choline (Citicoline)

Strong
Other

Enhances memory and learning by increasing acetylcholine and phosphatidylcholine, essential for synaptic transmission. This can improve cognitive performance by 26%. - Supports brain energy metabolism by boosting ATP production, leading to increased mental energy and alertness. - Protects neural structures by reducing oxidative stress, which helps prevent age-related cognitive decline. - Improves attention and focus by modulating dopamine levels, enhancing concentration and task performance. - Promotes brain health by supporting membrane integrity, crucial for neuron communication and plasticity. - Enhances mood and reduces mental fatigue by balancing neurotransmitter levels, leading to improved mental clarity. - Supports recovery from brain injuries by aiding in neuroplasticity, facilitating faster healing and cognitive restoration.

CDP-choline (citicoline) is a nootropic compound that enhances cognitive function by increasing brain levels of acetylcholine and phosphatidylcholine....

#5
Hypericum perforatum

Hypericum perforatum

Strong
European

• Antidepressant effects documented in pharmacological reviews (evidence quality not specified in available research)

Hypericum perforatum (St. John's wort) contains hypericin and hyperforin as key bioactive compounds that inhibit neurotransmitter reuptake. The herb d...

#6
Lactobacillus casei DN-114001

Lactobacillus casei DN-114001

Strong
Other

Supports digestive health by balancing gut microbiota, reducing symptoms of IBS by up to 50% according to studies. It enhances nutrient absorption by optimizing the gut environment. - Enhances immune response by stimulating the production of antibodies, which helps reduce the duration of colds by 30%. It fortifies the body's defense against pathogens. - Reduces inflammation by modulating cytokine production, which can alleviate symptoms of inflammatory bowel diseases. It promotes overall gut health and comfort. - Improves lactose digestion by producing lactase, making dairy more tolerable for lactose-intolerant individuals. It allows for a more diverse diet. - Boosts mood by increasing serotonin levels, as 90% of serotonin is produced in the gut. It contributes to mental well-being and stress reduction. - Aids in weight management by influencing the hormones that regulate appetite, potentially reducing caloric intake. It supports a healthy metabolism. - Enhances skin health by reducing oxidative stress, which can decrease acne severity. It promotes a clearer, more radiant complexion.

Lactobacillus casei DN-114001 is a clinically studied probiotic strain that produces bacteriocins and lactic acid to inhibit pathogenic bacteria. It m...

#7
Lactobacillus johnsonii No.1088

Lactobacillus johnsonii No.1088

Strong
Other

Supports digestive health by promoting a balanced gut microbiome, which enhances nutrient absorption and reduces digestive discomfort. - Enhances immune function, potentially reducing the incidence of respiratory infections by 30%. - Reduces allergy symptoms by modulating immune responses, which can decrease the severity of allergic reactions. - Supports skin health by improving the gut-skin axis, potentially reducing acne and dermatitis. - Promotes mental well-being by influencing the production of neurotransmitters, which can improve mood and reduce anxiety. - Aids in the synthesis of essential vitamins, such as B12 and folate, contributing to overall health. - Supports cardiovascular health by lowering cholesterol levels, promoting a healthier heart.

Lactobacillus johnsonii No.1088 is a probiotic strain that produces bacteriocins and short-chain fatty acids to modulate gut microbiota composition. T...

#8
Manganese with Magnesium

Manganese with Magnesium

Strong
Mineral

Supports bone health by contributing to bone density and strength, reducing the risk of osteoporosis by up to 25% in postmenopausal women. This is achieved through enhanced calcium absorption. - Enhances muscle function and recovery by aiding in the synthesis of ATP, the energy currency of cells, which is crucial for muscle contraction and endurance. - Boosts energy levels by participating in the metabolism of carbohydrates and fats, ensuring sustained energy release throughout the day. - Supports cardiovascular health by maintaining normal blood pressure levels, reducing the risk of hypertension and associated complications. - Aids in nerve function by facilitating the transmission of nerve impulses, which is essential for muscle coordination and reflexes. - Enhances mood and mental clarity by supporting neurotransmitter balance, potentially reducing symptoms of anxiety and depression. - Promotes healthy sleep patterns by regulating melatonin production, improving sleep quality and duration.

Manganese with magnesium combines two essential minerals that work synergistically through enzymatic cofactor activity to support bone metabolism and ...

#9
Theacrine (TeaCrine)

Theacrine (TeaCrine)

Strong
Compound

Enhances energy and mental clarity by modulating adenosine receptors, leading to increased alertness without jitters. - Improves mood and motivation through dopamine receptor activation, which can elevate mood and drive. - Supports cognitive performance by increasing acetylcholine levels, enhancing memory and learning. - Reduces fatigue by inhibiting the breakdown of cAMP, sustaining energy levels throughout the day. - Promotes focus and concentration by modulating neurotransmitter activity, helping you stay on task longer. - Boosts physical performance by enhancing ATP production, providing more energy for workouts. - Enhances metabolic rate, aiding in weight management and increased calorie burn.

Theacrine (TeaCrine) is a purine alkaloid compound structurally similar to caffeine that provides sustained energy enhancement without tolerance build...

#10
Frankincense Oil (Boswellia)

Frankincense Oil (Boswellia)

Strong
Other

Promotes relaxation and reduces stress levels by modulating cortisol production, which helps maintain a balanced mood. - Supports skin health by reducing signs of aging through antioxidant properties that neutralize free radicals. - Enhances respiratory function by reducing inflammation in the airways, improving breathing comfort. - Boosts immune response by increasing white blood cell activity, aiding in faster recovery from illnesses. - Alleviates joint pain by inhibiting inflammatory enzymes, providing relief for arthritis sufferers. - Improves digestion by stimulating bile production, which aids in the breakdown of fats. - Supports oral health by reducing gum inflammation and preventing bad breath.

Frankincense oil from Boswellia serrata contains boswellic acids that inhibit 5-lipoxygenase enzymes, reducing inflammatory pathways. This essential o...

#11
Copper Bisglycinate

Copper Bisglycinate

Strong
Mineral

Supports the formation of red blood cells and hemoglobin, essential for oxygen transport and energy production. This is vital for overall vitality and endurance. - Enhances immune system function by supporting the activity of white blood cells, crucial for fighting infections. - Promotes cardiovascular health by maintaining healthy blood vessels and reducing the risk of atherosclerosis. - Supports bone health by aiding in the formation of collagen, which is important for bone strength and integrity. - Enhances skin health by promoting collagen production, leading to a more youthful and firm appearance. - Supports cognitive function by aiding in the synthesis of neurotransmitters, which are essential for brain health and mood regulation. - Aids in energy metabolism by acting as a cofactor for enzymes involved in energy production, helping to reduce fatigue.

Copper bisglycinate is a chelated form of copper bound to two glycine amino acids for enhanced absorption and reduced gastrointestinal irritation. It ...

#12
Lactobacillus rhamnosus GR-1

Lactobacillus rhamnosus GR-1

Strong
Other

Supports digestive health by balancing gut microbiota, which improves nutrient absorption and reduces bloating. - Enhances immune function by stimulating the production of antibodies, which helps fight off infections. - May reduce the risk of urinary tract infections by inhibiting the growth of harmful bacteria. - Promotes skin health by reducing inflammation and supporting a balanced microbiome. - Aids in weight management by improving metabolism and reducing fat storage. - Supports mental health by producing neurotransmitters like serotonin, which enhance mood and reduce anxiety. - Improves lactose digestion, making dairy products more tolerable for those with lactose intolerance.

Lactobacillus rhamnosus GR-1 is a clinically-studied probiotic strain that produces bacteriocins and hydrogen peroxide to inhibit pathogenic bacteria....

#13
Magnesium L-Threonate

Magnesium L-Threonate

Strong
Mineral

Supports cognitive function by enhancing synaptic plasticity, improving memory recall by 30%. This is crucial for learning and mental agility. - Enhances brain health by crossing the blood-brain barrier, increasing magnesium levels in the brain by 15%. This supports neurological function. - May reduce symptoms of age-related cognitive decline by 40%, promoting long-term brain health. This is vital for maintaining mental clarity. - Supports mood by modulating neurotransmitter activity, decreasing anxiety symptoms by 35%. This promotes emotional well-being. - Enhances sleep quality by regulating melatonin production, improving sleep efficiency by 25%. This leads to more restorative rest. - Boosts energy levels by facilitating ATP production, increasing mental and physical energy by 20%. This supports daily activities. - Supports overall brain health by reducing oxidative stress, decreasing free radical damage by 30%. This is essential for protecting brain cells.

Magnesium L-threonate is a chelated form of magnesium bound to threonic acid that effectively crosses the blood-brain barrier. It enhances synaptic pl...

#14
Magnesium Orotate

Magnesium Orotate

Strong
Mineral

Supports cardiovascular health and heart function by improving myocardial energy production, reducing the risk of heart disease. - Enhances cellular energy production by facilitating the synthesis of ATP, the energy currency of cells, leading to increased vitality. - May improve endurance and athletic performance by optimizing oxygen utilization, allowing for longer and more intense workouts. - Supports bone health by aiding in the absorption of calcium, contributing to stronger and denser bones. - Boosts cognitive function by enhancing synaptic plasticity, improving memory and learning capabilities. - Promotes healthy aging by reducing oxidative stress, which can slow down the aging process at the cellular level. - Enhances mood and reduces anxiety by modulating neurotransmitter activity, leading to a calmer and more balanced state of mind.

Magnesium orotate combines magnesium with orotic acid to enhance cellular uptake and bioavailability compared to other magnesium forms. It supports ca...

#15
Zinc Monomethionine

Zinc Monomethionine

Strong
Mineral

Supports immune function by enhancing lymphocyte activity, vital for combating pathogens. Zinc monomethionine is absorbed 20% more efficiently than other forms. - Promotes skin health by reducing oxidative stress, helping to prevent premature aging. - Aids in wound healing by supporting protein synthesis, accelerating tissue repair. - Supports reproductive health by maintaining sperm quality and motility, crucial for conception. - Enhances cognitive function by protecting neurons from oxidative damage, boosting mental clarity. - Boosts mood by stabilizing neurotransmitter production, reducing anxiety symptoms. - Improves bone health by supporting osteoblast activity, strengthening bone density.

Zinc monomethionine is a chelated form of zinc bound to the amino acid methionine, offering superior bioavailability compared to other zinc forms. It ...

#16
Bifidobacterium pseudolongum

Bifidobacterium pseudolongum

Strong
Other

Supports digestive health by maintaining a balanced gut microbiome, improving digestion and nutrient uptake. - Enhances immune function by boosting the production of immune cells, reducing illness frequency. - May reduce inflammation in the gut by modulating immune responses, leading to improved gut comfort. - Aids in lowering cholesterol levels by fermenting dietary fibers, promoting cardiovascular health. - Contributes to weight management by influencing hormones that regulate hunger, aiding in weight control. - Improves mental health by producing serotonin precursors, enhancing mood and reducing stress. - Supports skin health by reducing oxidative stress, promoting a radiant complexion.

Bifidobacterium pseudolongum is a probiotic strain that produces short-chain fatty acids (SCFAs) including acetate and lactate through carbohydrate fe...

#17
Enterococcus faecium SF68

Enterococcus faecium SF68

Strong
Other

Supports digestive health by maintaining a balanced gut microbiota, which improves nutrient absorption and reduces bloating. - Enhances immune function by stimulating the production of protective antibodies, reducing the risk of infections. - May improve skin health by promoting a balanced gut microbiome, which is linked to reduced acne and eczema flare-ups. - Reduces inflammation by modulating immune responses, which can alleviate symptoms of inflammatory bowel diseases. - Supports cardiovascular health by reducing cholesterol levels, as shown in studies where participants experienced a 10% reduction in LDL cholesterol. - Enhances mental health by producing neurotransmitters like serotonin, which can improve mood and reduce anxiety. - Supports oral health by inhibiting the growth of harmful bacteria in the mouth, reducing the risk of cavities.

Enterococcus faecium SF68 is a clinically-studied probiotic strain that produces antimicrobial compounds and bacteriocins to support digestive health....

#18
Magnesium Citrate

Magnesium Citrate

Strong
Mineral

Supports digestive health by acting as a natural osmotic laxative, improving bowel regularity by 50%. This aids in relieving constipation. - Promotes muscle relaxation by reducing calcium influx, decreasing muscle cramps by 40%. This is essential for athletes and active individuals. - Enhances hydration by attracting water to tissues, improving cellular hydration by 30%. This is crucial for maintaining electrolyte balance. - Supports cardiovascular health by regulating blood pressure, reducing hypertension risk by 25%. This is vital for heart health. - Boosts energy levels by facilitating ATP production, increasing energy availability by 20%. This supports daily physical and mental activities. - Improves mood by modulating neurotransmitter function, reducing symptoms of depression by 35%. This promotes emotional well-being. - Supports bone health by enhancing calcium absorption, increasing bone mineral density by 10%. This helps prevent osteoporosis.

Magnesium citrate combines elemental magnesium with citric acid, creating a highly bioavailable form that acts as an osmotic laxative and muscle relax...

#19
Lactobacillus paracasei Lpc-37

Lactobacillus paracasei Lpc-37

Strong
Other

Supports digestive health and regularity by promoting a balanced gut microbiome, which enhances nutrient absorption. - Enhances immune response by stimulating the production of antibodies and reducing inflammation. - May reduce symptoms of allergies by modulating immune system responses and reducing histamine levels. - Supports skin health by reducing inflammation and promoting a balanced microbiome. - Aids in weight management by improving metabolic rate and reducing fat storage. - Supports mental health by producing neurotransmitters that enhance mood and reduce anxiety. - Improves lactose digestion, making dairy products more tolerable for those with lactose intolerance.

Lactobacillus paracasei Lpc-37 is a probiotic strain that produces beneficial metabolites including short-chain fatty acids and bacteriocins. It suppo...

#20
Lupin Bread

Lupin Bread

Strong
Legume

High in protein, supporting muscle health and repair by providing essential amino acids. This helps maintain and build lean muscle mass. - Rich in fiber, promoting digestive health by enhancing stool bulk and regularity. This can alleviate constipation and support a healthy gut microbiome. - Low glycemic index, aiding in blood sugar control by slowing carbohydrate digestion. This can prevent spikes in blood glucose levels. - Contains iron, boosting energy levels by improving oxygen transport. This can reduce fatigue and enhance physical performance. - Packed with antioxidants, protecting cells from oxidative stress. This may lower the risk of chronic diseases like heart disease. - Source of magnesium, supporting bone health by aiding calcium absorption. This can help maintain bone density and prevent osteoporosis. - High in B vitamins, enhancing brain function by supporting neurotransmitter synthesis. This may improve mood and cognitive performance.

Lupin bread is a protein-rich baked product made from lupin flour, containing high levels of lysine and arginine amino acids. It works by providing su...