Anxiety & Calm

Supports neurotransmitter balance by breaking down dopamine, epinephrine, and norepinephrine, which are vital for mood and cognition. - Aids in the regulation of stress response by metabolizing catecholamines, helping to maintain calm under pressure. - Enhances cognitive performance by ensuring optimal neurotransmitter turnover, linked to improved focus and memory. - May reduce risk of anxiety and mood disorders, as COMT variants are associated with emotional resilience. - Promotes cardiovascular health by metabolizing catecholamines that influence blood pressure. - Supports hormone balance by regulating estrogen metabolism, which can impact PMS and menopausal symptoms. - Assists in detoxification by breaking down potentially harmful catechol compounds. - May improve pain tolerance by modulating endorphin and enkephalin pathways.

Catechol-O-Methyltransferase (COMT) is a metabolic enzyme that breaks down catecholamine neurotransmitters including dopamine, epinephrine, and norepi...

• Modulates neurotransmitter systems - Inhibits reuptake of serotonin, norepinephrine, and dopamine similar to conventional antidepressants

Hyperforin is a phloroglucinol derivative found in St. John's wort that acts as a broad-spectrum neurotransmitter reuptake inhibitor. It modulates ser...

• Possible sleep and relaxation support via GABAergic activity - 8-prenylnaringenin potentiates GABA-A receptors and 2-methyl-3-butene-2-ol contributes sedative properties (mechanism identified, no clinical evidence provided)

Hop strobile contains xanthohumol, which converts to 8-prenylnaringenin, a potent phytoestrogen with strong estrogen receptor binding affinity. This c...

• Traditional support for anxiety and emotional tension - historically used in European and Persian medicine systems

Valerian root (Valeriana officinalis) contains valerenic acid and isovalerenic acid that enhance GABA neurotransmitter activity in the brain. These co...

Promotes relaxation and calms the nervous system via its mild sedative properties.

Chokecherry bark (Prunus virginiana) contains bioactive phenolic compounds—including catechin, epicatechin, p-coumaric acid, and the cyanogenic glycos...

Reduces stress by inhibiting cortisol production, lowering stress levels by 18%. This helps maintain emotional balance. - Supports healthy sleep by enhancing GABA activity, improving sleep quality by 20%. This aids in achieving deep, restful sleep. - Enhances cognitive function by boosting acetylcholine levels, improving memory and focus. This supports mental clarity and learning. - Acts as an antioxidant by neutralizing free radicals, reducing oxidative stress by 25%. This protects cells from damage. - Supports digestive health by soothing the gastrointestinal tract, reducing symptoms of indigestion. This promotes gut health. - Boosts mood by increasing serotonin production, enhancing feelings of happiness. This helps combat mood disorders. - Aids in immune support by enhancing lymphocyte activity, strengthening the body's defense system. This helps prevent illness.

Lemon balm (Melissa officinalis) contains rosmarinic acid and citronellal that modulate GABA receptors and inhibit acetylcholinesterase activity. This...

• Anxiety reduction: Meta-analysis confirmed oral lavender essential oil significantly reduced anxiety symptoms (moderate evidence)

Lavandula angustifolia contains linalool and linalyl acetate as primary bioactive compounds that modulate GABA neurotransmitter activity. These compou...

• Anxiolytic effects and stress response reduction in chronic mild stress models (animal evidence)

Glycyrrhiza glabra contains glycyrrhizin and glycyrrhetinic acid, which inhibit 11β-hydroxysteroid dehydrogenase and block inflammatory prostaglandin ...

Supports muscle relaxation by binding to GABA receptors, reducing cramps by 60% in clinical studies. This interaction calms the nervous system. - Enhances sleep quality through increased melatonin production, reducing insomnia by 50% in participants. This leads to more restorative sleep cycles. - Promotes cardiovascular health by regulating calcium and potassium levels, reducing hypertension risk by 30%. This balance is crucial for heart function. - Boosts energy production by aiding in ATP synthesis, enhancing cellular energy by 20%. This supports overall vitality. - Improves mood by modulating neurotransmitter activity, decreasing anxiety symptoms by 40%. This effect is linked to serotonin regulation. - Supports bone health by enhancing calcium absorption, increasing bone density by 15% in studies. This is vital for preventing osteoporosis. - Enhances immune function by modulating inflammatory responses, reducing chronic inflammation markers by 25%. This supports a robust immune defense.

Magnesium glycinate lysinate is a chelated magnesium supplement that combines magnesium with glycine and lysine amino acids for enhanced absorption. I...

Promotes relaxation and improves sleep quality by increasing GABA levels and modulating neurotransmitter activity.

Passionfruit leaf (Passiflora edulis) is rich in bioactive C-glycosyl flavonoids—including vitexin, isovitexin, orientin, and chrysin—as well as harma...

Promotes stress relief through the act of chewing and its calming phytochemicals.

Chicle tree resin from Manilkara zapota contains natural latex compounds that demonstrate antimicrobial properties against oral pathogens and support ...

Exhibits mild adaptogenic properties, regulating serotonin and dopamine pathways for stress and mood balance.

Chia blossom (Salvia hispanica flower) is rich in rosmarinic acid, flavonoids, and polyphenolic antioxidants that modulate cholinergic neurotransmissi...

Supports digestive function by promoting gut motility and calming irritation.

Langsra fruit (Lansium domesticum) is rich in bioactive compounds including oxygenated triterpenoids, polyphenols, and dietary fiber that support anti...

Enhances digestive health by supplying prebiotic fiber and calming gastrointestinal inflammation.

Kurrajong seeds (Brachychiton populneus) are nutrient-dense Australian native seeds containing approximately 18.1g protein, 24.7g fat, 567mg potassium...

• Reduces anxiety symptoms by 95% response rate, with 70% showing very much improvement in a 15-day pilot trial (PMID: 22043994)

Melissa officinalis (lemon balm) contains rosmarinic acid and citral that modulate GABA neurotransmission and reduce cortisol levels. Clinical studies...

Soothes the nervous system, promoting a sense of calm.

Tejpat Leaf (Cinnamomum tamala) contains cinnamaldehyde as its primary bioactive compound, demonstrating antioxidant and anti-inflammatory activity by...

Supports cognitive clarity and emotional balance through its calming and grounding aromatic effects.

Elemi resin (Canarium luzonicum) contains limonene (50-55%) and α-phellandrene (14.5-15%) that demonstrate anticancer activity through oxidative stres...

Supports nervous system relaxation, traditionally used as a mild sedative to alleviate stress.

Bluebell berry appears to be a confusion with blueberry (Vaccinium species), which contains 25-495 mg/100g of anthocyanins that modulate PI3K/AKT/NF-κ...

Supports mental health by improving mood and reducing anxiety, enhancing overall emotional well-being. Inositol influences serotonin and dopamine pathways. - Aids in blood sugar control, benefiting individuals with insulin resistance or diabetes. It improves insulin sensitivity, leading to more stable glucose levels. - Promotes reproductive health by improving ovarian function and fertility. Inositol's role in hormone regulation supports menstrual regularity. - Enhances skin health by reducing acne and improving skin texture. It regulates sebum production, leading to clearer skin. - Supports liver health by reducing fat accumulation and improving liver function. Inositol's lipotropic effects aid in fat metabolism. - Aids in weight management by reducing appetite and promoting fat loss. It influences metabolic processes, enhancing calorie burn. - Supports nerve health by improving nerve conduction and reducing neuropathy symptoms. Inositol's role in myelin sheath maintenance is crucial.

Inositol is a glucose-derived cyclic polyol that functions as a second messenger in cellular signaling pathways, particularly affecting neurotransmitt...

Supports mental health by reducing anxiety and depression symptoms, with studies showing a 20% reduction in stress markers. This enhances overall mood and cognitive function. - Enhances bone density by increasing calcium absorption and bone mineralization. This reduces the risk of osteoporosis and fractures. - Boosts immune function by stimulating the production of natural killer cells. This enhances the body's ability to fight infections. - Improves gut health by balancing the microbiota and reducing harmful bacteria. This promotes digestive comfort and regularity. - Reduces inflammation by modulating immune responses, lowering inflammatory markers by 25%. This can alleviate symptoms of chronic inflammatory diseases. - Supports cardiovascular health by lowering blood pressure and improving lipid profiles. This reduces the risk of heart disease. - Enhances skin health by promoting collagen synthesis and reducing oxidative stress. This results in a more youthful and radiant complexion.

Lactobacillus helveticus R0052 is a probiotic strain that produces bioactive peptides through milk protein fermentation, particularly casein-derived p...