Hermetica Superfood Encyclopedia
The Short Answer
Setria is a patented form of reduced glutathione (L-γ-glutamyl-L-cysteinyl-glycine) that directly elevates cellular glutathione levels. It functions as the body's master antioxidant by neutralizing free radicals and supporting phase II detoxification pathways.
CategoryBranded Ingredient
GroupOther
Evidence LevelModerate
Primary KeywordSetria reduced glutathione benefits
Synergy Pairings5
Setria (Reduced Glutathione) — botanical close-up
Health Benefits
Enhances detoxification by boosting liver function, increasing glutathione levels by 30%. This helps in the removal of toxins and supports liver health. - Strengthens the immune system by supporting white blood cell function, making the body more resilient against infections. This is vital for maintaining overall health. - Improves skin health by reducing oxidative stress, leading to a clearer, more radiant complexion. This can help reduce the appearance of blemishes and aging signs. - Supports respiratory health by reducing inflammation in the airways, which can alleviate symptoms of asthma and improve breathing. - Enhances energy levels by supporting mitochondrial function, leading to improved stamina and reduced fatigue. This is crucial for maintaining an active lifestyle. - Acts as a powerful antioxidant, protecting cells from damage and reducing the risk of chronic diseases. This promotes longevity and overall health. - Supports mental clarity by reducing oxidative stress in the brain, which can enhance focus and cognitive function.
Origin & History
Natural habitat
Setria is a branded form of reduced glutathione, a powerful antioxidant naturally produced in the body, manufactured through a fermentation process.
“Glutathione has been recognized for its health benefits in modern medicine, though it lacks a significant historical or cultural usage context.”Traditional Medicine
Scientific Research
Research, including clinical trials, supports Setria's role in enhancing antioxidant capacity and detoxification processes in the body.
Preparation & Dosage
Traditional preparation
Typical dosage ranges from 250 to 1000 mg per day. Consult a healthcare provider before use.
Nutritional Profile
Setria (Reduced Glutathione) is a tripeptide composed of three amino acids: L-glutamate, L-cysteine, and glycine, with a molecular weight of 307.32 g/mol. As a purified bioactive compound rather than a whole food, it lacks conventional macronutrient or micronutrient profiles. Key compositional data: Protein-equivalent content approximately 85-95% pure reduced glutathione (GSH) per serving, typically dosed at 250-500mg per serving in supplement form. The active thiol (-SH) group on the cysteine residue is the primary bioactive site responsible for antioxidant and detoxification activity. Sulfur content is notably significant due to the cysteine component, contributing to its redox-active properties. Bioavailability notes: Setria is a patented, fermentation-derived form of glutathione clinically demonstrated to resist gastric degradation better than standard glutathione; oral bioavailability studies show blood GSH levels increase by approximately 30-35% at 250mg/day dosing over 4 weeks. Lymphocyte glutathione concentrations have been shown to increase by up to 35% with consistent supplementation. Unlike standard glutathione supplements, Setria has demonstrated measurable increases in whole-blood glutathione in randomized controlled trials, indicating superior absorption compared to non-patented forms. No caloric, fiber, or conventional mineral content of significance.
How It Works
Mechanism of Action
Setria provides bioavailable reduced glutathione that directly increases intracellular GSH concentrations. It activates glutathione peroxidase and glutathione S-transferase enzymes, facilitating conjugation of toxins for elimination. The tripeptide also regenerates vitamins C and E while maintaining the reduced state of cysteine residues in proteins.
Clinical Evidence
Human studies demonstrate that Setria supplementation increases blood glutathione levels by 30% within 6 months at 500-1000mg daily doses. A randomized controlled trial with 54 adults showed significant improvements in oxidative stress markers and immune cell function. However, most clinical evidence comes from smaller studies lasting 6 months or less, with limited long-term safety data available.
Safety & Interactions
Setria is generally well-tolerated with minimal side effects reported at standard doses up to 1000mg daily. Some individuals may experience mild gastrointestinal upset, particularly on empty stomach. It may enhance the effects of chemotherapy drugs and should be used cautiously with immunosuppressive medications. Safety during pregnancy and breastfeeding has not been established in clinical trials.
Synergy Stack
Hermetica Formulation Heuristic
Also Known As
L-GlutathioneGSHReduced L-GlutathioneTripeptide Antioxidantγ-L-Glutamyl-L-cysteinylglycineMaster AntioxidantCellular Detoxifier
Frequently Asked Questions
How much Setria glutathione should I take daily?
Clinical studies typically use 250-1000mg of Setria daily, with 500mg being the most common effective dose. Most benefits are observed at 500mg taken once daily with food for optimal absorption.
How long does it take for Setria to increase glutathione levels?
Setria can increase blood glutathione levels within 1-2 weeks of supplementation. Maximum benefits typically occur after 3-6 months of consistent daily use at therapeutic doses.
Is Setria better absorbed than regular glutathione supplements?
Yes, Setria uses a proprietary fermentation process that creates a more bioavailable form of reduced glutathione. Studies show it increases blood levels more effectively than standard glutathione supplements.
Can I take Setria with other antioxidants like vitamin C?
Setria works synergistically with vitamin C and vitamin E, helping regenerate these antioxidants after they neutralize free radicals. Taking them together may enhance overall antioxidant protection.
Does Setria help with skin health and aging?
Clinical studies show Setria may improve skin elasticity and reduce melanin production when taken at 500mg daily for 12 weeks. It supports collagen synthesis and protects against UV-induced oxidative damage.
Does Setria glutathione interact with common medications?
Setria glutathione is generally well-tolerated with most medications, as it works through natural detoxification pathways rather than direct drug metabolism. However, if you take medications for autoimmune conditions or are on chemotherapy, consult your healthcare provider before supplementing, as glutathione's immune-enhancing effects may require dose adjustment. There are no major interactions with common over-the-counter pain relievers, antihistamines, or blood pressure medications.
Who should avoid Setria glutathione supplementation?
Individuals with cystic fibrosis or those on certain transplant medications should avoid Setria without medical supervision, as glutathione modulation may affect treatment outcomes. Pregnant and nursing women should consult their doctor before use, though current evidence suggests small supplemental doses are likely safe. People with severe glutathione synthetase deficiency or those allergic to any ingredient in the formulation should not use this product.
What does clinical research show about Setria's effectiveness for detoxification?
Clinical studies demonstrate that Setria can increase intracellular glutathione levels by approximately 30%, supporting the body's natural Phase II detoxification processes in the liver and kidneys. Research supports its role in reducing oxidative stress markers and enhancing liver function in healthy adults, though most studies involve relatively small sample sizes. The evidence is strongest for immune support and antioxidant protection, with emerging data on skin health and aging-related benefits.
Explore the Full Encyclopedia
7,400+ ingredients researched, verified, and formulated for optimal synergy.
Browse IngredientsThese statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.
hermetica-encyclopedia-canary-zzqv9k4w setria-reduced-glutathione curated by Hermetica Superfoods at ingredients.hermeticasuperfoods.com and licensed CC BY-NC-SA 4.0 (non-commercial share-alike, attribution required)
