Herbs (Global Traditional) · Southeast Asian
Sambiloto (Andrographis paniculata) (Andrographis paniculata)
Strong Evidencebotanical
Hermetica Superfood Encyclopedia
Sambiloto (Andrographis paniculata) contains andrographolide as its primary bioactive compound, which activates TRPV-4 channels to reduce inflammation. This traditional Jamu ingredient also demonstrates antimicrobial properties and immune system modulation through anaphylatoxin receptor antagonism.
Sambiloto (Andrographis paniculata) is a herbaceous plant native to South and Southeast Asia, belonging to the Acanthaceae family and traditionally used in Ayurvedic and traditional Chinese medicine systems. The herb is extracted from leaves and branches using ethanol or chloroform-based chromatography methods to isolate bioactive diterpenoids and flavonoids.
The research dossier does not contain specific human clinical trials, randomized controlled trials, or meta-analyses with PMIDs. While pharmacological properties including antiproliferative, antibacterial, antifungal, and anti-inflammatory effects are referenced, detailed clinical trial data with study designs and sample sizes are not available in the provided sources.
Standardized extracts contain andrographolide concentrations between 82-176 μg/mL, with capsules containing 550 mg of powder showing 2.68% andrographolide content. Some preparations contain up to 4.87% andrographolide. Specific clinically studied dosage ranges for human use are not provided in the available research. Consult a healthcare provider before starting any new supplement.
Sambiloto (Andrographis paniculata) is a medicinal herb with limited conventional macronutrient significance but rich in bioactive phytochemicals. Macronutrients per 100g dried leaf: protein ~8–12g, carbohydrates ~40–50g, dietary fiber ~15–20g, fat ~2–4g, moisture ~8–12g. Micronutrients include calcium (~1.2–1.8g/100g dried), potassium (~1.0–1.5g/100g), iron (~25–35mg/100g), and trace zinc and magnesium. Primary bioactive compounds: andrographolide (0.5–6% in dried leaves, the principal diterpene lactone responsible for most pharmacological activity), neoandrographolide (0.1–1.5%), 14-deoxyandrographolide (0.2–1.0%), andrograpanin (~0.1–0.5%), and arabinogalactan polysaccharides. Flavonoids present include apigenin, quercetin, and luteolin at ~0.2–0.5% total. Chlorogenic acid and other phenolic acids detected at ~0.3–0.8%. Bioavailability notes: andrographolide has poor aqueous solubility and moderate oral bioavailability (~25–30%) due to rapid hepatic metabolism and glucuronidation; peak plasma concentration reached within 1–2 hours post-ingestion. Lipid-based or nanoparticle formulations significantly enhance bioavailability by 2–4 fold. Piperine co-administration reported to improve absorption. Neoandrographolide, relevant to potential pain-relief mechanisms (neoandrog-), shows somewhat higher bioavailability due to glycoside modification. Standardized extracts typically normalized to 10–30% andrographolide content for therapeutic consistency.
Andrographolide, the primary active compound in sambiloto, activates TRPV-4 (transient receptor potential vanilloid 4) channels, leading to anti-inflammatory responses. The compound also acts as an anaphylatoxin receptor antagonist, modulating immune system responses. Additional diterpene lactones contribute to antimicrobial effects by disrupting bacterial cell wall synthesis and inhibiting viral replication.
Current research on sambiloto focuses primarily on in vitro and animal studies demonstrating anti-inflammatory and antimicrobial mechanisms. While the TRPV-4 channel activation and anaphylatoxin receptor antagonism have been identified at the molecular level, robust clinical trials in humans are limited. Most evidence supporting traditional uses comes from laboratory studies rather than large-scale human trials. The antimicrobial properties have shown promise in preliminary studies but require further clinical validation.
Sambiloto may cause gastrointestinal upset, headache, and fatigue in some individuals at higher doses. The herb can potentially interact with anticoagulant medications due to its blood-thinning properties and may enhance hypoglycemic effects when combined with diabetes medications. Pregnant and breastfeeding women should avoid sambiloto as safety data is insufficient. Individuals with autoimmune conditions should consult healthcare providers before use due to immune system effects.
