Hermetica Superfood Encyclopedia
The Short Answer
Myricitrin, a flavonoid and Myricetin 3-O-rhamnoside, exhibits potent antioxidant properties by reducing oxidative stress markers. It shows preliminary evidence for blood sugar regulation through increased glycogen content and Glut-4 gene expression.
CategoryNamed Bioactive Compounds
GroupCompound
Evidence LevelModerate
Primary KeywordMyricitrin benefits
Synergy Pairings5
Myricitrin (Myricetin 3-O-rhamnoside) — botanical close-up
Health Benefits
Origin & History
Natural habitat
Myricitrin (myricetin 3-O-rhamnoside) is a flavonoid glycoside derived primarily from plants such as Myrica rubra and Elaeocarpus floribundus (Indian olive tree), occurring naturally in various fruits, vegetables, and teas. It is extracted from plant sources like leaves or bark using standard phytochemical methods including solvent extraction or chromatography.
“No specific historical or traditional medicinal uses are documented for myricitrin in the available sources. While source plants like Myrica rubra and Elaeocarpus floribundus suggest potential ethnobotanical relevance, traditional applications are not detailed in the research.”Traditional Medicine
Scientific Research
No human clinical trials, RCTs, or meta-analyses specifically on myricitrin are identified in the available sources, with evidence limited to preclinical studies. In vitro studies used myricitrin at 1-10 μM concentrations in C2C12 mouse myoblast cells, showing antioxidant effects over 48 hours. Reviews emphasize the critical need for comprehensive clinical research to establish human efficacy.
Preparation & Dosage
Traditional preparation
No clinically studied dosage ranges are reported for myricitrin in human trials. Preclinical in vitro studies used 1-10 μM concentrations, but human equivalent doses have not been established. Consult a healthcare provider before starting any new supplement.
Nutritional Profile
{"macronutrients": {"fiber": "Not applicable", "protein": "Not applicable"}, "micronutrients": {"vitamins": "Not applicable", "minerals": "Not applicable"}, "bioactive_compounds": {"myricetin": "Present as myricitrin, a glycoside form", "rhamnose": "Present as part of the myricitrin structure"}, "bioavailability_notes": "Myricitrin is a glycoside of myricetin, which may affect its absorption and metabolism. The glycoside form can influence the compound's solubility and stability, potentially impacting its bioavailability."}
How It Works
Mechanism of Action
Myricitrin exerts antioxidant effects by directly scavenging free radicals and upregulating endogenous antioxidant enzymes such as superoxide dismutase (SOD) and catalase (CAT). In preclinical hyperglycemia models, it reduces malondialdehyde (MDA) levels, indicating decreased lipid peroxidation. Additionally, Myricitrin has been shown to enhance glycogen content and increase Glut-4 gene expression in mouse myoblast cells, suggesting a role in glucose uptake and utilization.
Clinical Evidence
Current research on Myricitrin primarily consists of in vitro studies and preclinical animal models. Preliminary evidence from preclinical hyperglycemia models demonstrates Myricitrin's ability to reduce oxidative stress markers like MDA while enhancing antioxidant enzyme activities (SOD, CAT). In vitro studies using mouse myoblast cells indicate increased glycogen content and Glut-4 gene expression, suggesting potential benefits for blood sugar support. Human clinical trials are currently lacking, so these findings are considered preliminary and require further investigation to confirm efficacy and safety in humans.
Safety & Interactions
The safety profile of Myricitrin in humans is not well-established due to the limited number of human clinical trials. Based on its classification as a flavonoid, it is generally considered to have a low toxicity potential. However, specific side effects, drug interactions, or contraindications for Myricitrin have not been thoroughly documented. As a precautionary measure, pregnant or breastfeeding individuals and those on medication should consult a healthcare professional before use.
Synergy Stack
Hermetica Formulation Heuristic
Also Known As
Myricetin 3-O-rhamnosideMyricetin 3-rhamnosideMyricetin-3-O-α-L-rhamnopyranoside3-RhamnosylmyricetinMyrica rubra flavonoidMYR
Frequently Asked Questions
What is Myricitrin?
Myricitrin is a natural flavonoid, specifically a glycoside of myricetin, known chemically as Myricetin 3-O-rhamnoside. It is found in various plants and contributes to their beneficial health properties.
How does Myricitrin act as an antioxidant?
Myricitrin functions as an antioxidant by directly scavenging reactive oxygen species and upregulating the activity of endogenous antioxidant enzymes. Preclinical studies show it reduces oxidative stress markers like malondialdehyde (MDA) and enhances superoxide dismutase (SOD) and catalase (CAT) activity.
Does Myricitrin support blood sugar?
In vitro evidence suggests Myricitrin may support blood sugar regulation. Studies in mouse myoblast cells demonstrated it increases glycogen content and Glut-4 gene expression, indicating enhanced glucose uptake and storage.
Where is Myricitrin found naturally?
As a flavonoid, Myricitrin is naturally present in various plant-based foods and herbs. It is often found in fruits, vegetables, and medicinal plants where myricetin is also present.
Are there any clinical trials on Myricitrin?
Currently, research on Myricitrin is predominantly limited to in vitro studies and preclinical animal models. Human clinical trials are lacking, meaning its efficacy and safety in humans have not yet been conclusively established.
What is the difference between Myricitrin and Myricetin?
Myricitrin is a glycoside form of myricetin, meaning myricetin is bound to a rhamnose sugar molecule (making it Myricetin 3-O-rhamnoside), while myricetin is the free aglycone. The glycosidic bond in myricitrin may affect absorption, metabolism, and bioavailability compared to unconjugated myricetin. Some research suggests the glycoside form may have different tissue distribution and metabolic pathways in the body.
Can I get enough Myricitrin from dietary sources alone?
Myricitrin is found in foods like blueberries, bilberries, and certain plant materials, but typical dietary amounts are relatively modest. Achieving therapeutic levels comparable to research doses (often in the mg to gram range) through diet alone would require consuming large quantities of these foods consistently. Most individuals using myricitrin for health support rely on concentrated supplements to reach the doses studied in preclinical research.
Who should avoid Myricitrin supplementation?
While myricitrin is generally well-tolerated as a plant-derived compound, individuals on blood-thinning medications, those with upcoming surgery, and people with severe kidney or liver disease should consult a healthcare provider before supplementing. Pregnant and nursing women lack sufficient safety data and should avoid supplementation unless specifically advised by their physician. Those with known hypersensitivity to flavonoids or related compounds should exercise caution.
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