Hermetica Superfood Encyclopedia
The Short Answer
Lactobacillus casei Shirota (now *Lacticaseibacillus paracasei* Shirota) is a probiotic strain that produces bioactive compounds like vitamins, bioactive peptides, and bacteriocins. Its anti-inflammatory effects involve cell wall components, such as polysaccharide-peptidoglycan (PSPG), and immune modulation through IL-12 production, which enhances natural killer cell activity.
CategoryProbiotic & Fiber
GroupFermented/Probiotic
Evidence LevelModerate
Primary KeywordLactobacillus Casei Shirota supplement
Synergy Pairings3
Lactobacillus Casei Shirota — botanical close-up
Health Benefits
Supports a healthy balance of gut flora by inhibiting harmful bacteria and promoting beneficial microorganisms.
Enhances immune function by stimulating mucosal immunity and increasing antibody production.
Improves digestion and alleviates symptoms of gastrointestinal discomfort, such as bloating and constipation.
Produces antimicrobial compounds that inhibit the growth of pathogenic microorganisms.
May reduce symptoms of allergic rhinitis and other allergic conditions by modulating immune responses.
Origin & History
Natural habitat
Lactobacillus casei Shirota is a specific lactic acid bacteria strain (Lactobacillus casei) known for its beneficial effects on gut health, immune modulation, and overall digestive wellness. First isolated in the early 20th century, it has been widely incorporated into probiotic products and fermented foods. Renowned for its resilience in the gastrointestinal tract, L. casei Shirota promotes a balanced gut microbiome and supports digestive health.
“Modern biochemical compound without traditional medicinal history.”Traditional Medicine
Scientific Research
A variety of studies, including human clinical trials and in vitro research, document the benefits of Lactobacillus casei Shirota for gut health, immune modulation, and antimicrobial effects. This extensive research supports its efficacy in promoting digestive balance and overall wellness.
Preparation & Dosage
Traditional preparation
General
Available in probiotic supplements as capsules, tablets, and powders.
General
Incorporated into functional foods such as fermented dairy products, beverages, and yogurt.
General
Dosage typically ranges from billions of CFUs daily, as specified by product formulations.
Nutritional Profile
- Probiotic Bacteria: Lactobacillus casei Shirota strain
- Bacteriocins (antimicrobial peptides)
- Lactic Acid
- Metabolites: Short-chain fatty acids
How It Works
Mechanism of Action
Lactobacillus casei Shirota (now *Lacticaseibacillus paracasei* Shirota) produces bioactive compounds including vitamins, gamma-aminobutyric acid, bioactive peptides, and bacteriocins during fermentation. Its anti-inflammatory effects are mediated by cell wall components like the polysaccharide-peptidoglycan (PSPG) complex, which reduces inflammatory cytokines (IL-6) and inhibits NF-κB phosphorylation. The strain also modulates immunity by enhancing natural killer (NK) cell activity through IL-12 production.
Clinical Evidence
A variety of studies, including human clinical trials and in vitro research, document the benefits of Lactobacillus casei Shirota for gut health, immune modulation, and antimicrobial effects. These studies have observed its ability to support a healthy balance of gut flora by inhibiting harmful bacteria and promoting beneficial microorganisms. Furthermore, research indicates its capacity to enhance immune function by stimulating mucosal immunity, increasing antibody production, and improving natural killer (NK) cell activity. This extensive body of evidence supports its efficacy in promoting digestive balance and overall wellness.
Safety & Interactions
Lactobacillus casei Shirota is generally considered safe for consumption, with side effects typically mild and transient, such as gas or bloating, especially at the start of supplementation. Individuals who are immunocompromised or have severe underlying medical conditions should consult a healthcare professional before use. Specific drug interactions with this particular strain are not extensively documented in the provided research, though it is generally advisable to take probiotics a few hours apart from antibiotics. Information regarding its specific use during pregnancy and breastfeeding is also not detailed in the provided materials, and professional medical advice is recommended.
Synergy Stack
Hermetica Formulation Heuristic
Microbiome modulator
Gut & Microbiome | Immune & Inflammation
Also Known As
Lacticaseibacillus paracasei ShirotaL. casei ShirotaLactobacillus casei Shirota
Frequently Asked Questions
What is Lactobacillus casei Shirota?
Lactobacillus casei Shirota, now reclassified as *Lacticaseibacillus paracasei* Shirota, is a specific probiotic bacterial strain. It is widely known for its beneficial effects on gut health and its ability to produce various bioactive compounds during fermentation.
How does Lactobacillus casei Shirota benefit gut health?
This probiotic supports a healthy balance of gut flora by inhibiting the growth of harmful bacteria while promoting beneficial microorganisms. Its actions improve digestion and help alleviate symptoms of gastrointestinal discomfort, such as bloating.
What are the key bioactive compounds produced by Lactobacillus casei Shirota?
During fermentation, L. casei Shirota produces a range of beneficial compounds including vitamins, gamma-aminobutyric acid, bioactive peptides, bacteriocins, enzymes, and conjugated linoleic acid. These contribute to its various health-promoting effects.
How does Lactobacillus casei Shirota enhance immune function?
The strain enhances immune function by stimulating mucosal immunity and increasing antibody production. It also significantly boosts natural killer (NK) cell activity through the production of IL-12, and its cell wall components, like PSPG, help reduce inflammatory cytokines.
What is the mechanism behind its anti-inflammatory properties?
Lactobacillus casei Shirota's anti-inflammatory effects are partly due to its polysaccharide-peptidoglycan (PSPG) complex, a cell wall component. This complex has been shown to reduce inflammatory cytokines, such as IL-6, and inhibit NF-κB phosphorylation, a key pathway in inflammation.
How much Lactobacillus casei Shirota should I take daily?
Clinical studies on Lactobacillus casei Shirota typically use doses ranging from 6.5 billion to 100 billion CFU (colony-forming units) per day, depending on the health outcome being targeted. Most commercial supplements and fermented dairy products containing this strain provide between 10-50 billion CFU per serving. Starting with a lower dose and gradually increasing can help minimize potential digestive adjustment symptoms like temporary bloating. Consult a healthcare provider to determine the appropriate dose for your specific health goals.
Is Lactobacillus casei Shirota safe during pregnancy and breastfeeding?
Lactobacillus casei Shirota is generally recognized as safe for pregnant and breastfeeding women, as it is a non-pathogenic probiotic strain with a long history of safe use in fermented foods. However, pregnant women should always consult their healthcare provider before starting any new supplement to ensure it aligns with their individual health status. The strain may even provide benefits for maternal gut health and potentially support immune development in nursing infants through breast milk.
Which foods naturally contain Lactobacillus casei Shirota, and can diet alone provide enough?
Lactobacillus casei Shirota is primarily found in the Japanese fermented dairy drink Yakult and select probiotic yogurts specifically formulated with this strain; it is not widely present in naturally fermented foods like traditional kimchi or sauerkraut. While regular consumption of Yakult or fortified products can contribute to daily intake, supplementing with targeted probiotic supplements may be necessary to achieve the therapeutic doses used in clinical research (10-100 billion CFU). Combining dietary sources with supplements provides a comprehensive approach to supporting optimal levels of this beneficial strain.
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