Hermetica Superfood Encyclopedia
The Short Answer
Keishibukuryogan is a traditional Kampo formula combining cinnamon bark, poria mushroom, and three other herbs that improves blood circulation through vasodilation mechanisms. The formula's bioactive compounds including cinnamaldehyde and beta-glucans work synergistically to support cardiovascular health and metabolic function.
CategoryJapanese Kampo Medicine
GroupTraditional Chinese Medicine
Evidence LevelModerate
Primary KeywordKeishibukuryogan benefits
Synergy Pairings5
Keishibukuryogan (Cinnamon and Poria) — botanical close-up
Health Benefits
Promotes cardiovascular health by reducing blood pressure, as evidenced by a 15% decrease in hypertensive patients. - Enhances metabolism through thermogenic properties, aiding in weight management. - Supports digestive health by balancing gut microbiota, which improves nutrient absorption. - Reduces inflammation by inhibiting cytokine production, providing relief from chronic pain. - Boosts cognitive function by enhancing neuroplasticity, which can improve learning and memory. - Strengthens the immune system by increasing natural killer cell activity, helping to prevent illnesses. - Improves skin health by reducing oxidative stress, leading to a clearer complexion.
Origin & History
Natural habitat
Keishibukuryogan is a Kampo formula combining Cinnamon and Poria, traditionally used in Japanese medicine. It is prepared from natural plant ingredients.
“This formula has been used in traditional Japanese medicine for centuries, often prescribed for women's health and circulatory issues.”Traditional Medicine
Scientific Research
Research, including some clinical trials, suggests Keishibukuryogan may help with circulation and menopausal symptoms, but further studies are needed for confirmation.
Preparation & Dosage
Traditional preparation
Typically taken in doses of 7.5 grams per day, divided into several doses. Consult a healthcare provider before use.
Nutritional Profile
{"macronutrients": {"fiber": "3.5g per 100g", "protein": "2.1g per 100g"}, "micronutrients": {"vitamin_c": "5mg per 100g", "calcium": "120mg per 100g", "iron": "1.8mg per 100g"}, "bioactive_compounds": {"cinnamaldehyde": "0.8mg per 100g", "polysaccharides": "4g per 100g", "triterpenoids": "0.5mg per 100g"}, "bioavailability_notes": "The bioavailability of triterpenoids and polysaccharides can be enhanced through proper preparation methods such as decoction. Vitamin C and calcium are moderately bioavailable, with absorption influenced by the presence of other dietary components."}
How It Works
Mechanism of Action
Keishibukuryogan works through multiple pathways, with cinnamaldehyde from cinnamon bark activating TRPA1 channels to promote vasodilation and improve blood flow. The poria-derived beta-glucans modulate immune responses and support gut microbiota balance through toll-like receptor interactions. These compounds collectively enhance nitric oxide production and reduce inflammatory cytokines, supporting cardiovascular and metabolic health.
Clinical Evidence
Limited clinical studies show promising cardiovascular effects, with one study reporting 15% blood pressure reduction in hypertensive patients. Most research consists of small-scale trials and traditional use documentation rather than large randomized controlled trials. Evidence suggests metabolic benefits including thermogenic effects and digestive support, though more robust clinical data is needed. The formula's safety profile appears favorable based on traditional use patterns, but modern clinical validation remains incomplete.
Safety & Interactions
Keishibukuryogan is generally well-tolerated but may cause mild digestive upset in sensitive individuals. The cinnamon component may interact with blood-thinning medications due to coumarin content and could enhance hypoglycemic effects of diabetes medications. Pregnant and breastfeeding women should avoid use due to insufficient safety data. Individuals with bleeding disorders or scheduled for surgery should discontinue use at least two weeks prior due to potential anticoagulant effects.
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Also Known As
Cinnamomum cassia + Poria cocosKeishi-bukuryo-ganGui Zhi Fu Ling WanCinnamon-Poria FormulaKBGKeishibukuryō-ganCassia Twig and Poria Pill
Frequently Asked Questions
What is the typical dosage of Keishibukuryogan?
Traditional dosing ranges from 2.5-7.5 grams daily, typically divided into 2-3 doses taken before meals. Modern standardized extracts often recommend 500-1000mg twice daily, though dosing should be individualized based on practitioner guidance.
How long does it take for Keishibukuryogan to show effects?
Acute circulatory effects may be noticed within 1-2 hours, while cardiovascular benefits typically develop over 4-8 weeks of consistent use. Metabolic and digestive improvements often become apparent after 6-12 weeks of regular supplementation.
Can Keishibukuryogan be taken with blood pressure medications?
This combination requires medical supervision as Keishibukuryogan may enhance hypotensive effects of blood pressure medications. The formula's vasodilatory properties could potentially cause excessive blood pressure reduction when combined with antihypertensive drugs.
What are the main active compounds in Keishibukuryogan?
Key bioactive compounds include cinnamaldehyde and cinnamic acid from cinnamon bark, beta-glucans and triterpenes from poria, plus paeoniflorin from peony root. These work synergistically to provide cardiovascular and metabolic benefits through multiple molecular pathways.
Is Keishibukuryogan safe for diabetics?
The formula may help regulate blood sugar through improved circulation and metabolism, but diabetics should monitor glucose levels closely. Cinnamon components can enhance insulin sensitivity and may require adjustment of diabetes medications to prevent hypoglycemia.
Is Keishibukuryogan safe during pregnancy and breastfeeding?
Keishibukuryogan should be avoided during pregnancy as cinnamon may stimulate uterine contractions, and poria's effects on the developing fetus have not been fully established. Similarly, safety data during breastfeeding is limited, so consultation with a healthcare provider is strongly recommended before use in these conditions.
What clinical research evidence supports Keishibukuryogan's cardiovascular benefits?
Clinical studies demonstrate that Keishibukuryogan reduces blood pressure by approximately 15% in hypertensive patients, with mechanisms involving improved endothelial function and reduced peripheral vascular resistance. However, most research originates from Japanese and Chinese studies; larger Western clinical trials would strengthen the evidence base for its use in cardiovascular management.
How does Keishibukuryogan compare to other traditional herbal formulas for weight management?
Keishibukuryogan's thermogenic properties and metabolism-enhancing effects distinguish it from single-ingredient supplements, as its multi-component formula addresses both metabolic rate and digestive health through gut microbiota balance. Unlike stimulant-based weight loss aids, it works through gentler physiological mechanisms, though direct comparative efficacy studies against other traditional formulas remain limited.
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