Hermetica Superfood Encyclopedia
The Short Answer
Fisetin is a flavonoid polyphenol found in strawberries and apples that exhibits potent senolytic activity by selectively eliminating senescent cells. This compound activates autophagy pathways and modulates SIRT1 activity to support cognitive function and healthy aging.
CategoryExtract & Compound
GroupCompound
Evidence LevelModerate
Primary Keywordfisetin benefits
Synergy Pairings4
Fisetin — botanical close-up
Health Benefits
Supports cognitive health by promoting neuroprotection, which can enhance memory and learning capabilities. - Exhibits anti-inflammatory and antioxidant properties, reducing oxidative stress and inflammation in the brain. - Promotes healthy aging by activating pathways that enhance cellular repair and longevity. - Enhances mood and reduces anxiety by modulating neurotransmitter levels, improving mental well-being. - Supports cardiovascular health by reducing arterial plaque formation, lowering the risk of heart disease. - Boosts immune function by enhancing the body's defense mechanisms against infections. - Aids in detoxification by promoting the elimination of toxins, improving overall health and vitality.
Origin & History
Natural habitat
Fisetin is a naturally occurring flavonoid found in fruits and vegetables like strawberries, apples, and onions. It is extracted from these sources or synthesized for supplements. Fisetin is recognized for its antioxidant and anti-inflammatory properties.
“Fisetin has been studied for its health benefits since the early 20th century. It is traditionally consumed through a diet rich in fruits and vegetables.”Traditional Medicine
Scientific Research
Research, including animal studies and some human trials, supports fisetin's role in cognitive and cardiovascular health. Emerging evidence suggests benefits for healthy aging.
Preparation & Dosage
Traditional preparation
Typical dosage ranges from 100-500 mg per day. Consult a healthcare provider before use.
Nutritional Profile
- Flavonoid with potent antioxidant and anti-inflammatory properties.
- Found in strawberries, apples, and onions.
- Bioavailability varies based on food source and preparation.
How It Works
Mechanism of Action
Fisetin activates the transcription factor Nrf2, enhancing antioxidant enzyme production and reducing oxidative stress. It demonstrates senolytic activity by inducing apoptosis in senescent cells through p53/p21 pathway modulation. The compound also activates SIRT1 and AMPK pathways, promoting autophagy and mitochondrial biogenesis for cellular repair and longevity.
Clinical Evidence
Human clinical data for fisetin remains limited, with most evidence derived from animal and in vitro studies. A small pilot study (n=24) examining fisetin supplementation in older adults showed potential cognitive benefits, though larger trials are needed. Preclinical studies demonstrate significant senolytic effects at doses of 20mg/kg in mice, equivalent to approximately 100-500mg daily in humans. Current evidence suggests promising neuroprotective and anti-aging potential, but robust human clinical trials are required to confirm therapeutic efficacy.
Safety & Interactions
Fisetin appears well-tolerated in preliminary human studies, with no serious adverse effects reported at doses up to 100mg daily. The compound may interact with anticoagulant medications due to its potential blood-thinning properties. Limited data exists regarding pregnancy and breastfeeding safety, so use should be avoided during these periods. Individuals with bleeding disorders or those scheduled for surgery should consult healthcare providers before supplementation.
Synergy Stack
Hermetica Formulation Heuristic
Also Known As
3,3',4',7-tetrahydroxyflavone3,7,3',4'-tetrahydroxyflavone5-deoxyquercetinCI Natural Yellow 10CI 75660Fisetholz extractSmoketree extractCotinus extract
Frequently Asked Questions
What foods naturally contain fisetin?
Strawberries contain the highest concentration of fisetin at approximately 160μg per gram, followed by apples (26.9μg/g) and persimmons. Other sources include onions, grapes, and cucumbers, though in much lower concentrations.
How much fisetin should I take daily?
Clinical studies have used doses ranging from 20-100mg daily, though optimal dosing remains unclear. Most commercial supplements provide 100mg per serving, typically taken with meals to enhance absorption.
Can fisetin help with brain fog and memory?
Preliminary studies suggest fisetin may support cognitive function through its neuroprotective and anti-inflammatory effects. However, human clinical evidence is limited, and more research is needed to confirm cognitive benefits.
Is fisetin better than other senolytic compounds?
Fisetin demonstrates strong senolytic activity in preclinical studies and has better bioavailability than some other senolytics like quercetin. However, direct comparative human studies are lacking to definitively establish superiority.
How long does it take to see fisetin benefits?
The timeline for fisetin benefits varies by individual and intended use. Acute antioxidant effects may occur within hours, while senolytic and anti-aging benefits likely require weeks to months of consistent supplementation.
Does fisetin interact with common medications?
Fisetin may interact with blood thinners and antiplatelet medications due to its mild anticoagulant properties, so consult your healthcare provider if you're on warfarin or similar drugs. It can also affect medications metabolized by cytochrome P450 enzymes, potentially altering their efficacy. Always inform your doctor about fisetin supplementation before starting new medications to ensure safety.
What is the most bioavailable form of fisetin?
Fisetin has relatively low natural bioavailability, with most oral doses being poorly absorbed in the small intestine. Supplemental forms with enhanced absorption technology, liposomal delivery, or co-formulation with fat-soluble compounds and black pepper extract (piperine) may improve bioavailability. Research suggests that taking fisetin with dietary fats and certain adjuvants can significantly increase its systemic availability compared to standalone powder forms.
Who should avoid taking fisetin supplements?
Pregnant and breastfeeding women should avoid fisetin due to limited safety data in these populations. Individuals taking anticoagulants, antiplatelet drugs, or immunosuppressants should consult their doctor before supplementing, as fisetin may potentiate these effects. People with bleeding disorders or those scheduled for surgery should also avoid fisetin supplementation without medical clearance.
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