Di-Caffeine Malate (Infinergy)

Di-Caffeine Malate (Infinergy™) is a patented compound consisting of approximately 75% caffeine and 25% malic acid bonded ionically. Per 100 mg of Di-Caffeine Malate, approximately 73-75 mg is anhydrous caffeine and 25-27 mg is malic acid. It contains no significant macronutrients (protein, fat, carbohydrates, or fiber) and no appreciable vitamins or minerals. The primary bioactive compound is caffeine (1,3,7-trimethylxanthine), a methylxanthine alkaloid that acts as an adenosine receptor antagonist and phosphodiesterase inhibitor. The malic acid component is a dicarboxylic acid involved in the Krebs cycle (citric acid cycle), contributing to cellular energy (ATP) production. Typical supplemental doses range from 50-300 mg of Di-Caffeine Malate (yielding ~37-225 mg active caffeine). Bioavailability of caffeine from this form is high (>90% oral absorption), similar to standard caffeine anhydrous, but the malic acid buffering slows the rate of gastric absorption, resulting in a more gradual pharmacokinetic curve with delayed peak plasma concentration (Tmax extended by approximately 15-30 minutes compared to caffeine anhydrous alone). This delayed release reduces gastric irritation and provides more sustained plasma caffeine levels. The half-life of the caffeine component remains approximately 3-7 hours depending on individual CYP1A2 enzyme activity. Malic acid itself has high bioavailability and is rapidly metabolized through normal mitochondrial pathways. The compound contains no sugars, no cholesterol, no sodium, and no fat-soluble vitamins. It is calorie-free at standard supplemental doses.