Hermetica Superfood Encyclopedia
The Short Answer
Deglycyrrhizinated licorice (DGL) contains glycyrrhetinic acid derivatives that enhance gastric mucus production and reduce inflammatory prostaglandin synthesis. DGL supports gastrointestinal healing by strengthening mucosal defense mechanisms and reducing stomach acid irritation.
CategoryLeaf & Herb
GroupOther
Evidence LevelStrong
Primary KeywordDGL benefits
Synergy Pairings4
Deglycyrrhizinated Licorice (DGL) — botanical close-up
Health Benefits
Supports gastrointestinal health by soothing the stomach lining, which can alleviate symptoms of indigestion and heartburn. This is achieved through its anti-inflammatory properties that reduce irritation. - May help in managing symptoms of peptic ulcers by promoting mucosal defense mechanisms. Studies show a 50% reduction in ulcer size with regular use. - Aids in reducing stress-induced gastric issues by modulating cortisol levels. This helps maintain a balanced digestive environment. - Enhances liver function by promoting detoxification processes. It supports the liver's ability to filter toxins from the bloodstream. - Boosts immune function by increasing the production of lymphocytes. This strengthens the body's defense against infections. - May reduce inflammation in the body by inhibiting pro-inflammatory cytokines. This can lead to improved overall health and reduced chronic disease risk. - Supports respiratory health by soothing irritated airways. This is particularly beneficial for those with chronic respiratory conditions.
Origin & History
Natural habitat
Deglycyrrhizinated Licorice (DGL) is derived from the root of the Glycyrrhiza glabra plant, native to Europe and Asia. The glycyrrhizin compound is removed to reduce potential side effects, leaving beneficial flavonoids and chalcones.
“Used in traditional Chinese and Ayurvedic medicine for its soothing effects on the digestive system. Revered for its sweet flavor and healing properties.”Traditional Medicine
Scientific Research
Studies, including clinical trials, have shown DGL's effectiveness in treating gastric ulcers and reducing acid reflux symptoms. In vitro research supports its anti-inflammatory effects.
Preparation & Dosage
Traditional preparation
Commonly taken as chewable tablets, 380-760 mg before meals. Consult a healthcare provider before use.
Nutritional Profile
- Contains flavonoids like liquiritin and isoliquiritin. - Rich in chalcones and glycyrrhizin-free compounds. - Provides essential oils and polysaccharides.
How It Works
Mechanism of Action
DGL's flavonoids and chalcones stimulate prostaglandin E2 synthesis, which increases protective gastric mucus and bicarbonate secretion. The compound inhibits 15-hydroxyprostaglandin dehydrogenase, prolonging prostaglandin activity that promotes mucosal healing. DGL also reduces inflammatory cytokine production through NF-κB pathway modulation.
Clinical Evidence
Human studies using 380-1140mg DGL daily for 4-12 weeks show significant improvement in dyspepsia symptoms and peptic ulcer healing rates of 60-90%. A randomized controlled trial with 120 participants found DGL as effective as ranitidine for ulcer treatment. However, most studies are small-scale with 30-120 subjects, and larger long-term trials are needed to confirm therapeutic efficacy.
Safety & Interactions
DGL is generally well-tolerated with minimal side effects, unlike whole licorice which can cause hypertension and potassium depletion. May interact with anticoagulant medications by potentially enhancing bleeding risk. Pregnant and breastfeeding women should consult healthcare providers before use. Individuals with hormone-sensitive conditions should use caution due to potential estrogenic activity.
Synergy Stack
Hermetica Formulation Heuristic
Also Known As
Glycyrrhiza glabraDGLLicorice root extractYashtimadhuGan CaoSweet rootLiquorice
Frequently Asked Questions
What is the difference between DGL and regular licorice?
DGL has glycyrrhizin removed, eliminating the blood pressure and potassium-lowering effects of regular licorice. This makes DGL safer for long-term use while preserving the stomach-protective compounds like flavonoids and chalcones.
How much DGL should I take for stomach ulcers?
Clinical studies typically use 380-760mg of DGL taken 20 minutes before meals, three times daily. Some protocols use up to 1140mg daily divided into multiple doses for active ulcer treatment.
How long does DGL take to work for heartburn?
DGL may provide relief within 15-30 minutes when chewed before meals due to direct mucosal contact. For sustained benefits in chronic conditions, consistent use for 4-8 weeks is typically needed based on clinical trials.
Can DGL help with acid reflux and GERD?
DGL may help GERD by increasing protective mucus production and reducing inflammatory damage to the esophageal lining. However, specific clinical data for GERD is limited compared to peptic ulcer research.
Should DGL be chewed or swallowed whole?
DGL tablets should be chewed rather than swallowed whole to allow direct contact with gastric mucosa and saliva activation. Chewing releases active compounds and enhances the protective coating effect on stomach lining.
Is DGL safe to take long-term for chronic digestive issues?
DGL is generally considered safe for long-term use since the glycyrrhizin (which can raise blood pressure) has been removed, making it suitable for extended supplementation. However, some individuals may experience mild side effects like nausea or headaches with prolonged use. It's advisable to consult with a healthcare provider before using DGL continuously for more than 8–12 weeks to ensure it remains appropriate for your condition. Those with severe kidney disease or on blood pressure medications should seek professional guidance before starting.
Does DGL interact with common medications like antacids or H2 blockers?
DGL does not have significant direct interactions with common antacids (like calcium carbonate) or H2 blockers (like famotidine), and can often be used alongside them. However, DGL's stomach-soothing effects work through different mechanisms than these medications, so combining them should be discussed with a pharmacist or doctor. DGL may theoretically reduce stomach acid slightly, which could affect the absorption timing of acid-sensitive medications, so spacing doses by 2 hours is recommended. Always inform your healthcare provider of all supplements and medications you're taking to ensure safety.
Who should avoid DGL, and are there any contraindications?
People with a history of licorice sensitivity or allergies should avoid DGL, though true allergic reactions are rare since most glycyrrhizin has been removed. Individuals with severe hypertension, kidney disease, or hormonal conditions (like estrogen-dependent cancers) should consult a doctor before use, as some licorice compounds may still have minor effects. Pregnant and breastfeeding women should seek professional advice before supplementing with DGL, as safety data in these populations is limited. DGL is generally well-tolerated in children but should only be given under parental guidance and healthcare supervision.
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