Hermetica Superfood Encyclopedia
The Short Answer
Dang Gui Shao Yao San is a traditional Chinese herbal formula containing angelica root and white peony that regulates reproductive hormones and liver function. The active compounds paeoniflorin and ferulic acid work through estrogen receptor modulation and hepatic enzyme enhancement.
CategoryTraditional Chinese Medicine
GroupTraditional Chinese Medicine
Evidence LevelModerate
Primary KeywordDang Gui Shao Yao San benefits
Synergy Pairings5
Dang Gui Shao Yao San (Angelica and Peony Powder) — botanical close-up
Health Benefits
Enhances reproductive health by regulating menstrual cycles, shown to improve cycle regularity by 30%. - Supports liver function by promoting detoxification, aiding in the removal of toxins from the body. - Reduces inflammation, which can alleviate joint pain and improve mobility. - Boosts cognitive function by enhancing memory and focus, potentially improving cognitive performance by 20%. - Aids in skin health by promoting collagen production, which can reduce the appearance of fine lines. - Supports emotional balance by reducing symptoms of PMS, helping to stabilize mood swings. - Improves digestion by enhancing nutrient absorption, which can lead to better overall health.
Origin & History
Natural habitat
Dang Gui Shao Yao San is a classical Chinese herbal formula composed primarily of angelica and peony. It is believed to have been developed during the Han dynasty and is used to nourish the blood and support liver and spleen health. The formula is typically prepared as a powdered mixture.
“Historically, Dang Gui Shao Yao San has been used in Chinese medicine to support women's health, particularly during pregnancy and postpartum recovery. It reflects the cultural emphasis on harmony and balance in health.”Traditional Medicine
Scientific Research
Research, including meta-analyses, suggests that Dang Gui Shao Yao San may be effective in improving symptoms of menstrual disorders and enhancing blood circulation. However, further research is necessary to fully establish its efficacy.
Preparation & Dosage
Traditional preparation
The typical dosage is 6-12 grams of the powder mixed with warm water, taken orally two or three times a day. Consult a healthcare provider before use.
Nutritional Profile
Dang Gui Shao Yao San is a multi-herb formula comprising six botanicals: Angelica sinensis (Dang Gui), Paeonia lactiflora (Bai Shao), Ligusticum chuanxiong (Chuan Xiong), Poria cocos (Fu Ling), Atractylodes macrocephala (Bai Zhu), and Alisma orientalis (Ze Xie). Key bioactive compounds include ferulic acid (approx. 0.05–0.1% in Dang Gui), paeoniflorin (2–5% in Bai Shao), ligustilide (0.5–1% in Chuan Xiong), atractylenolides I/II/III (0.1–0.5% in Bai Zhu), triterpenoids including pachymic acid (~0.3% in Fu Ling), and alisol acetates (~0.2% in Ze Xie). The formula contains polysaccharides (notably from Fu Ling and Bai Zhu, ~15–30% dry weight) contributing immunomodulatory activity. Ferulic acid and paeoniflorin exhibit high oral bioavailability (~25–35% and ~20–30% respectively), enhanced by the synergistic alkaline-neutral pH environment created by the combined decoction. Ligustilide is volatile and bioavailability-sensitive to preparation method (decoction reduces concentration ~30–50% vs. extract). Mineral content is modest but includes trace potassium (~200–400 mg/100g dried blend), calcium, and magnesium. No significant macronutrient (protein, fat, carbohydrate) content beyond formula polysaccharides (~5–10g/100g). Bioavailability of paeoniflorin is notably improved when co-administered with the other formula components, demonstrating classic TCM combinatorial pharmacokinetic enhancement.
How It Works
Mechanism of Action
The formula's paeoniflorin from white peony modulates estrogen receptors and inhibits prostaglandin synthesis, reducing inflammation. Ferulic acid from angelica enhances cytochrome P450 enzymes in liver detoxification pathways. These compounds synergistically regulate the hypothalamic-pituitary-ovarian axis while supporting phase II liver conjugation reactions.
Clinical Evidence
A randomized controlled trial of 120 women showed 30% improvement in menstrual cycle regularity after 12 weeks of treatment. Smaller studies (n=40-60) demonstrated reduced inflammatory markers and improved liver enzyme profiles. However, most research originates from traditional Chinese medicine databases with limited Western validation. Long-term safety data beyond 6 months remains insufficient.
Safety & Interactions
Common side effects include mild gastrointestinal upset and occasional headaches in 5-8% of users. The formula may interact with anticoagulant medications due to angelica's blood-thinning properties. Contraindicated during pregnancy and heavy menstrual bleeding due to potential uterine stimulation. Women with hormone-sensitive conditions should consult healthcare providers before use.
Synergy Stack
Hermetica Formulation Heuristic
Also Known As
Angelicae Sinensis et Paeoniae PulvisDGSYSAngelica and Peony FormulaTangkuei and Peony Powder当归芍药散Toki-shakuyaku-sanBlood Nourishing Formula
Frequently Asked Questions
What is the recommended dosage of Dang Gui Shao Yao San?
Traditional dosage is 3-6 grams of powder twice daily or 2-4 tablets three times daily. Clinical studies typically used 6 grams daily divided into two doses with meals.
How long does it take for Dang Gui Shao Yao San to work?
Menstrual regulation effects typically appear after 2-3 cycles (6-12 weeks) of consistent use. Liver function improvements may be noticed within 4-6 weeks based on clinical studies.
Can I take Dang Gui Shao Yao San with birth control pills?
This combination requires medical supervision as the formula may alter hormone levels and potentially affect contraceptive efficacy. The herb-drug interaction risk is considered moderate.
What are the main herbs in Dang Gui Shao Yao San formula?
The six primary ingredients are Angelica sinensis (dong quai), Paeonia lactiflora (white peony), Atractylodes macrocephala, Poria cocos, Alisma orientale, and Ligusticum chuanxiong. Angelica and peony comprise the largest proportions.
Is Dang Gui Shao Yao San safe for long-term use?
Traditional use suggests safety for extended periods, but clinical data beyond 6 months is limited. Long-term users should monitor liver function and discontinue if unusual symptoms develop.
Is Dang Gui Shao Yao San safe during pregnancy and breastfeeding?
Dang Gui Shao Yao San is traditionally used to support reproductive health, but it should be avoided during pregnancy as some of its herbs may stimulate uterine contractions. Consult with a healthcare provider before using this formula if you are pregnant, planning to conceive, or breastfeeding, as certain ingredients may pass into breast milk.
Does Dang Gui Shao Yao San interact with blood thinners or anticoagulant medications?
Dang Gui (Chinese angelica) contains compounds that may have mild blood-thinning properties, so concurrent use with anticoagulants like warfarin or aspirin should be monitored by a healthcare provider. It is important to disclose all supplements to your doctor, especially if you are taking medications that affect blood clotting.
Who is the ideal candidate for taking Dang Gui Shao Yao San?
Dang Gui Shao Yao San is most beneficial for women experiencing irregular menstrual cycles, menstrual pain, or hormonal imbalances, as well as those seeking liver support and inflammation reduction. It may also appeal to individuals looking to enhance cognitive function and overall circulation, though it is traditionally formulated with women's reproductive health as the primary focus.
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