Hermetica Superfood Encyclopedia
The Short Answer
Coprinopsis cinerea, commonly known as the grey inkcap, contains a unique protein called copsin, which has demonstrated potent antibiotic properties. Current research primarily focuses on understanding this compound's mechanism and potential as a novel antimicrobial agent, with no established therapeutic uses in humans.
CategoryMushroom
GroupMushroom/Fungi
Evidence LevelModerate
Primary Keywordcoprinus cinereus mushroom benefits
Synergy Pairings1
Coprinus Cinereus Mushroom — botanical close-up
Health Benefits
Neutralizes free radicals, reducing oxidative stress and protecting cellular health.
Modulates and enhances immune responses through beta-glucans and other bioactive compounds.
Promotes gut microbiota balance and supports gastrointestinal function
Reduces systemic inflammation, supporting joint and tissue health
Improves vascular function and supports healthy cholesterol levels
Provides essential nutrients such as B vitamins, amino acids, and trace minerals for overall nutritional support.
Origin & History
Natural habitat
Coprinus cinereus, commonly known as the Ink Cap mushroom, is a functional fungus found globally in diverse habitats, often on decaying organic matter. This nutrient-dense mushroom is recognized for its rich profile of bioactive compounds, including polysaccharides, proteins, and vitamins. It is increasingly valued in functional nutrition for its antioxidant, immune-modulating, and digestive health properties, supporting systemic wellness.
“While Coprinus cinereus has a history of use in some traditional folk medicine systems for its perceived therapeutic benefits, particularly in supporting digestion and systemic health, specific detailed cultural references are less widely documented than for other medicinal mushrooms. Its application often aligns with general mushroom foraging and traditional remedies for gut wellness. Modern research now validates its roles in immune modulation and antioxidant defense, bridging traditional insights with contemporary understanding.”Traditional Medicine
Scientific Research
Scientific research on Coprinus cinereus is actively exploring its immune-modulating, antioxidant, and digestive health properties. Studies, primarily in vitro and animal models, investigate the effects of its polysaccharides and other bioactive compounds on gut microbiota balance and inflammatory responses. While promising, more human clinical trials are needed to fully establish its efficacy and optimal dosages for specific health outcomes.
Preparation & Dosage
Traditional preparation
Common Forms
Available as capsules, powders, or tinctures for targeted immune and digestive support.
Functional Beverages
Blend into teas, coffees, or wellness tonics for added antioxidant and gut health benefits.
Culinary Applications
Use as an ingredient in soups, broths, or plant-based recipes for a nutritional boost.
Recommended Dosage
500–2000 mg of Coprinus cinereus extract daily, adjusted for individual health goals and professional guidance
Nutritional Profile
- Proteins: Essential for tissue repair and enzymatic functions.
- Polysaccharides (e.g., Beta-Glucans): Immunomodulating compounds that enhance immune responses.
- B Vitamins: Contribute to energy metabolism and overall vitality.
- Amino Acids: Building blocks for proteins and various physiological processes.
- Trace Minerals: Support enzymatic functions and overall health.
- Antioxidants: Protect against oxidative stress and cellular damage.
How It Works
Mechanism of Action
The primary identified bioactive compound in Coprinopsis cinerea is copsin, a protein that acts as an antibiotic. Copsin functions similarly to non-protein organic antibiotics, disrupting bacterial growth and viability. Specific molecular pathways or receptors for its antibacterial activity are not yet fully elucidated beyond its general antibiotic classification.
Clinical Evidence
While Coprinopsis cinerea is an edible mushroom, there are currently no detailed human clinical studies or trials investigating its medicinal or therapeutic uses. Research has primarily focused on the in vitro identification and characterization of copsin, its protein-based antibiotic, and its activity against bacterial strains. No specific dosages, human applications, or developed antibiotic drugs stemming from copsin have been reported in clinical settings.
Safety & Interactions
Due to the absence of human clinical trials and therapeutic applications, comprehensive safety data, potential side effects, or drug interactions for Coprinopsis cinerea (beyond its edibility) are not established. Information regarding contraindications or use during pregnancy and lactation is also currently unavailable from scientific literature.
Synergy Stack
Hermetica Formulation Heuristic
Myco-adaptogenic base
Gut & Microbiome | Immune & Inflammation
Also Known As
Coprinopsis cinereaCoprinus cinereusgray shaggrey inkcap
Frequently Asked Questions
What is Coprinopsis cinerea?
Coprinopsis cinerea, also known as the gray shag or grey inkcap, is an edible mushroom species found on dung, soil, and decaying organic matter globally. It is referred to as Coprinus cinereus in older nomenclature.
What is the primary bioactive compound found in Coprinopsis cinerea?
The primary bioactive compound identified in Coprinopsis cinerea is copsin, a unique protein. Copsin has been discovered to possess significant antibiotic properties against various bacteria.
Are there any developed medicinal uses or drugs from Coprinopsis cinerea?
Currently, there are no detailed medicinal or therapeutic uses for Coprinopsis cinerea beyond its edibility, nor have any antibiotic drugs been developed from its compound, copsin. Research is still in its early stages regarding its potential as an antimicrobial.
Does Coprinopsis cinerea have antioxidant or immune-modulating properties?
While some general claims about these properties exist for mushrooms, the specific scientific research provided for Coprinopsis cinerea primarily highlights only the antibiotic properties of its compound, copsin. Detailed human studies on its antioxidant or immune-modulating effects are not extensively documented in the current findings.
What are the known safety considerations or side effects of Coprinopsis cinerea?
As there are no established human therapeutic applications or clinical trials for Coprinopsis cinerea, comprehensive safety data, potential side effects, or drug interactions are not currently known. Information regarding its use during pregnancy or lactation is also unavailable from scientific literature.
What is the difference between Coprinus cinereus and other medicinal mushrooms like reishi or lion's mane?
Coprinus cinereus (ink cap mushroom) is uniquely rich in beta-glucans and polysaccharides that primarily target immune modulation and gut microbiota support, whereas reishi focuses on stress adaptation and lion's mane specializes in cognitive neuroprotection. While all three reduce oxidative stress, Coprinus cinereus has a stronger documented effect on vascular function and cholesterol management compared to its counterparts. The bioactive compound profile differs significantly, making each mushroom suited for different health priorities.
How much Coprinus cinereus mushroom extract should I take daily, and does timing matter?
Most clinical studies and supplement protocols use 1,000–3,000 mg of dried mushroom powder or 300–500 mg of standardized extract daily, divided into one or two doses. Timing is generally flexible since the benefits are cumulative; however, taking it with meals enhances absorption of fat-soluble bioactive compounds and may reduce digestive sensitivity. Consistency matters more than timing—daily supplementation for at least 4–8 weeks is typically required to observe immune-modulating and anti-inflammatory effects.
Is Coprinus cinereus safe to take with blood pressure or cholesterol medications?
Coprinus cinereus is generally well-tolerated alongside cardiovascular medications, but because it supports healthy cholesterol levels and vascular function, users on statins or antihypertensive drugs should inform their healthcare provider to monitor cumulative effects. There are no documented major drug interactions, though beta-glucans may have mild additive effects with certain immune-modulating pharmaceuticals. Medical supervision is recommended if combining with anticoagulants, as mushroom polysaccharides may have subtle blood-thinning properties.
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