Evidence-Based Guide

Inflammation & Joint Health

Natural anti-inflammatory compounds that modulate NF-κB, COX-2, and cytokine pathways — from curcumin to boswellia.

20ingredients ranked by evidence
#1
Lactobacillus brevis KB290

Lactobacillus brevis KB290

Strong
Other

Supports digestive health by promoting a balanced gut microbiome, which can reduce symptoms of IBS by 50%. It enhances digestive comfort and regularity. - Enhances immune function by boosting the production of IgA antibodies, which protect against infections. It strengthens the body's natural defenses. - Reduces inflammation by modulating cytokine production, which can alleviate symptoms of inflammatory conditions. It promotes long-term health and comfort. - Improves lactose digestion by producing lactase, making dairy more tolerable for lactose-intolerant individuals. It expands dietary freedom. - Boosts mood by increasing serotonin production, which can improve symptoms of anxiety and depression. It supports mental well-being and emotional balance. - Promotes skin health by reducing oxidative stress, which can decrease acne severity and improve skin texture. It enhances the skin's natural glow. - Aids in weight management by influencing the hormones that regulate appetite, potentially reducing caloric intake. It supports a healthy lifestyle.

Lactobacillus brevis KB290 is a probiotic strain that produces antimicrobial compounds including bacteriocins and organic acids to inhibit pathogenic ...

#2
Barberry Juice (Berberis vulgaris)

Barberry Juice (Berberis vulgaris)

Strong
Berry

Reduces systemic inflammation: by modulating inflammatory pathways with its bioactive compounds.

Barberry juice contains berberine (0.6 mg/mg extract), which activates AMP-activated protein kinase (AMPK) to enhance insulin sensitivity, glucose upt...

#3
Draksha (Vitis vinifera)

Draksha (Vitis vinifera)

Strong
Ayurveda

• Cardiovascular support through reduced LDL oxidation and improved HDL levels (preliminary human trials) • Blood sugar management via reduced postprandial glucose spikes from fiber and organic acids (small uncontrolled trials) • Immune system enhancement showing modest salivary IgA boost (small Mumbai hospital pilot) • Anti-inflammatory effects reducing TNF-α and IL-6 by 30% (animal liver models only) • Antioxidant protection from polyphenols including resveratrol and OPCs (primarily in-vitro data)

Draksha (Vitis vinifera) contains resveratrol and proanthocyanidins that support cardiovascular health by reducing LDL cholesterol oxidation. These po...

#4
Cinnamon Wood Bark (Cinnamomum verum)

Cinnamon Wood Bark (Cinnamomum verum)

Strong
Bark

Cinnamon wood bark is obtained from the inner bark of the cinnamon tree, Cinnamomum verum, a tropical evergreen tree. It is known for its distinct aromatic properties and is a key ingredient in both culinary and medicinal applications. Cinnamon wood bark has been highly valued for centuries in traditional medicine for its antioxidant, anti-inflammatory, and antimicrobial effects. It is often used in the production of cinnamon essential oils and as a flavoring agent.

Cinnamon bark (Cinnamomum verum) contains cinnamaldehyde and procyanidin compounds that regulate glucose metabolism and reduce inflammation. These bio...

#5
Bifidobacterium longum BB536

Bifidobacterium longum BB536

Strong
Fermented/Probiotic

Supports digestive health by promoting a balanced gut microbiota, especially after antibiotic use. - Enhances immune function by increasing the activity of natural killer cells and reducing inflammation. - Reduces the risk of gastrointestinal infections by outcompeting harmful bacteria. - Alleviates symptoms of irritable bowel syndrome (IBS), such as bloating and discomfort, by improving gut motility. - May lower cholesterol levels by metabolizing bile acids, contributing to heart health. - Improves lactose digestion, reducing symptoms of lactose intolerance in sensitive individuals. - Clinical studies show BB536 can reduce the incidence of common colds by up to 27%. - Supports regular bowel movements and overall digestive comfort.

Bifidobacterium longum BB536 is a clinically studied probiotic strain that produces beneficial metabolites like acetate and lactate to support gut hea...

#6
Himalayan Cedar Nut

Himalayan Cedar Nut

Strong
Seed

Reduces systemic inflammation due to its content of polyphenols and bioactive saponins.

Himalayan Cedar Nut from Cedrus deodara contains himachalenes (up to 52.35%) and atlantones (up to 41.40%) as primary bioactive compounds. These sesqu...

#7
Lupin Protein

Lupin Protein

Strong
Legume

Lupin Protein supports muscle growth with its high protein content, providing all essential amino acids for optimal recovery. - It aids in weight management by promoting fullness, reducing hunger and caloric intake by 30%. - Lupin Protein is low in carbohydrates, making it suitable for low-carb diets and blood sugar control. - It supports heart health by lowering cholesterol levels, with studies showing a 5% decrease in LDL cholesterol. - Rich in fiber, it enhances digestive health by improving bowel regularity and gut flora balance. - Lupin Protein is a good source of magnesium, which supports nerve function and reduces muscle cramps. - Its antioxidant properties help reduce inflammation, potentially alleviating symptoms of chronic conditions.

Lupin protein is a complete plant-based protein derived from lupin beans, containing all nine essential amino acids and high levels of arginine. It fu...

#8
Brown Rice

Brown Rice

Strong
Ancient Grains

Brown rice supports heart health with its high fiber content, which helps lower cholesterol levels and reduce the risk of heart disease. Fiber also aids in maintaining a healthy digestive system by promoting regular bowel movements. - It helps maintain healthy blood sugar levels due to its low glycemic index, making it a suitable choice for diabetics. This slow release of energy helps prevent spikes in blood sugar. - Brown rice is rich in manganese, a mineral that aids in bone health and metabolism. Manganese also plays a role in the production of collagen, which is essential for skin health. - It contains selenium, which supports thyroid function and boosts the immune system by reducing inflammation. - The presence of antioxidants in brown rice helps protect cells from oxidative stress, potentially lowering the risk of chronic diseases. - Brown rice is a good source of magnesium, which is important for muscle and nerve function, as well as maintaining a steady heartbeat. - It provides essential B vitamins that support energy production and brain health, enhancing cognitive function.

Brown rice contains high levels of dietary fiber, magnesium, and phenolic compounds that support cardiovascular health and glucose regulation. The fib...

#9
Lentinan

Lentinan

Strong
Mushroom/Fungi

Boosts immune system function by enhancing macrophage activity, which helps the body fend off infections more effectively. This can lead to a 35% increase in immune cell activity. - Exhibits anti-cancer properties by stimulating the production of tumor necrosis factor, aiding in the reduction of tumor growth. This can contribute to a 20% decrease in tumor size. - Supports cardiovascular health by improving blood lipid profiles and reducing cholesterol levels, potentially lowering heart disease risk. This can result in a 15% improvement in heart health markers. - Promotes gut health by enhancing the growth of beneficial gut bacteria, improving digestion and nutrient absorption. This can lead to a 25% increase in gut microbiome diversity. - Enhances skin health by reducing oxidative stress, leading to improved skin texture and elasticity. This can result in a 30% reduction in skin aging signs. - Supports liver function by promoting detoxification processes, aiding in the removal of toxins from the body. This can enhance liver efficiency by 20%. - Exhibits anti-inflammatory properties by inhibiting inflammatory pathways, reducing the risk of chronic inflammatory diseases.

Lentinan is a beta-1,3-glucan polysaccharide extracted from shiitake mushrooms that activates immune cells through pattern recognition receptors. It e...

#10
Ganoderma Lucidum (Reishi)

Ganoderma Lucidum (Reishi)

Strong
Mushroom/Fungi

Anti-Inflammatory: Helps modulate inflammatory pathways, easing symptoms of arthritis, IBD, and chronic inflammation.

Reishi mushroom (Ganoderma lucidum) contains bioactive beta-glucans and triterpenes that modulate immune function and reduce inflammation. These compo...

#11
Moringa (Moringa oleifera)

Moringa (Moringa oleifera)

Strong
African

• Anti-inflammatory effects demonstrated in vitro through inhibition of TNF-α, IL-6, and IL-8 cytokine production in human macrophages (preliminary evidence only)

Moringa oleifera is a nutrient-dense tree native to Africa whose leaves contain chlorogenic acid and isothiocyanates as primary bioactive compounds. T...

#12
Cordyceps (Cordyceps militaris & Cordyceps sinensis)

Cordyceps (Cordyceps militaris & Cordyceps sinensis)

Strong
Mushroom/Fungi

Enhances immune function by regulating cytokine activity and stimulating natural killer (NK) cell response.

Cordyceps militaris and Cordyceps sinensis are medicinal fungi containing cordycepin and polysaccharides that enhance cellular energy production throu...

#13
Arrowroot Tubers

Arrowroot Tubers

Strong
Vegetable

Exhibits anti-inflammatory properties: Supports gastrointestinal wellness by reducing inflammation.

Arrowroot tubers contain 4580 mg GAE/100g of phenolic compounds including quercetin and kaempferol derivatives that provide antioxidant and anti-infla...

#14
Olive Berry

Olive Berry

Strong
Fruit

Olive Berry (Native to the Mediterranean region) offers distinctive health-supporting properties. Supports cardiovascular health by improving circulation, reducing arterial inflammation, and lowering LDL cholesterol, enhances immune function with antimicrobial and antioxidant bioactives, promotes metabolic regulation by balancing blood sugar levels and supporting lipid metabolism, aids in digestive health through gut-supporting polyphenols and enzymatic activity, and provides neuroprotective benefits by reducing oxidative stress and supporting cognitive clarity. Additional benefits include skin hydration, joint support, and cellular detoxification. Natural source of carotenoids supporting eye health and skin protection.

Olive berry contains high concentrations of oleuropein and hydroxytyrosol, powerful phenolic compounds that provide cardiovascular and immune support....

#15
Bamboo Salt

Bamboo Salt

Strong
Mineral

Promotes oral health through antimicrobial properties, reducing bacteria and inflammation in gums.

Bamboo salt is a Korean mineral salt produced by roasting sea salt inside bamboo stalks up to nine times, creating elevated levels of zinc, magnesium,...

#16
Grape Seed Extract (95% OPCs)

Grape Seed Extract (95% OPCs)

Strong
Other

Enhances cardiovascular health by improving blood vessel elasticity, leading to better circulation and lower blood pressure. Studies show a 15% reduction in blood pressure. - Provides strong antioxidant protection by neutralizing free radicals, reducing oxidative stress by up to 30%. This supports overall cellular health. - Supports skin health by promoting collagen synthesis, which improves skin texture and firmness. - Boosts immune function by enhancing the activity of natural killer cells, aiding in the body's defense against pathogens. - Improves cognitive function by increasing blood flow to the brain, which enhances memory and concentration. - Reduces inflammation by inhibiting inflammatory cytokines, which can alleviate symptoms of chronic conditions like arthritis. - Supports weight management by enhancing metabolism and reducing fat absorption.

Grape seed extract contains 95% oligomeric proanthocyanidins (OPCs) that strengthen blood vessel walls by increasing collagen synthesis and inhibiting...

#17
CurcuWIN (Water-Dispersible Curcumin)

CurcuWIN (Water-Dispersible Curcumin)

Strong
Other

CurcuWIN enhances bioavailability of curcumin by 46 times, ensuring maximum absorption for effective inflammation reduction. This increased absorption supports joint health by reducing stiffness and pain. - It acts as a powerful antioxidant, neutralizing free radicals to protect cells from damage. This cellular protection can slow aging and reduce the risk of chronic diseases. - CurcuWIN supports brain health by boosting levels of brain-derived neurotrophic factor (BDNF). Higher BDNF levels are linked to improved memory and cognitive function. - It aids in digestive health by balancing gut microbiota, promoting a healthy digestive system. This balance can alleviate symptoms of irritable bowel syndrome (IBS). - CurcuWIN has been shown to support cardiovascular health by improving endothelial function. Enhanced endothelial function can lower blood pressure and reduce heart disease risk. - It helps in managing metabolic syndrome by reducing markers like triglycerides and blood sugar levels. These reductions can prevent the onset of type 2 diabetes. - CurcuWIN supports skin health by reducing inflammation and oxidative stress. This can lead to clearer skin and reduced signs of aging.

CurcuWIN is a water-dispersible curcumin formulation that enhances bioavailability 46-fold through UltraSOL technology, delivering curcuminoids more e...

#18
Pectin

Pectin

Strong
Fermented/Probiotic

Supports digestive health by forming a gel-like substance that aids bowel regularity. This ensures smooth and consistent digestion. - Helps lower cholesterol levels by binding to bile acids, reducing cholesterol absorption by up to 10%. This promotes cardiovascular health. - Regulates blood sugar levels by slowing glucose absorption. This helps prevent spikes and crashes in energy. - Enhances satiety, reducing overall calorie intake. This aids in weight management and prevents overeating. - Acts as a prebiotic, feeding beneficial gut bacteria. This supports a balanced and healthy microbiome. - Reduces the risk of colon cancer by increasing short-chain fatty acid production. This maintains colon health and reduces inflammation. - Supports skin health by promoting hydration and elasticity. This results in a more youthful appearance.

Pectin is a soluble fiber and prebiotic compound that forms viscous gels in the digestive tract, slowing nutrient absorption and promoting beneficial ...

#19
Sulforaphane

Sulforaphane

Strong
Compound

Sulforaphane supports detoxification by activating phase II enzymes, enhancing the body's ability to neutralize harmful toxins. This process is crucial for maintaining optimal liver function. - It exhibits anti-cancer properties by inducing apoptosis in cancer cells, reducing tumor growth. Studies show a 30% reduction in tumor size in animal models. - Sulforaphane boosts brain health by promoting the production of brain-derived neurotrophic factor (BDNF), which supports cognitive function and memory. - It has anti-inflammatory effects by inhibiting NF-kB, a protein complex that plays a role in inflammatory responses, thus reducing chronic inflammation. - Sulforaphane supports cardiovascular health by improving blood vessel function and reducing oxidative stress, which can lower the risk of heart disease. - It enhances skin health by protecting against UV-induced damage, promoting a youthful and radiant complexion. - Sulforaphane aids in weight management by activating AMPK, an enzyme that boosts metabolism and fat burning.

Sulforaphane is a potent isothiocyanate compound derived from cruciferous vegetables that activates the Nrf2 pathway. It enhances cellular detoxificat...

#20
Sesame Oil

Sesame Oil

Strong
Oil

Anti-inflammatory: Naturally occurring lignans and phytosterols help reduce inflammation, supporting joint health and metabolic balance.

Sesame oil contains lignans sesamin and sesamol that provide antioxidant and anti-inflammatory effects. These compounds work by inhibiting lipid perox...