Evidence-Based Guide

Energy & Vitality

Sustained energy without the crash — adaptogenic and mitochondrial compounds that enhance ATP production, oxygen utilization, and endurance.

20ingredients ranked by evidence
#1
Cordyceps (Cordyceps militaris & Cordyceps sinensis)

Cordyceps (Cordyceps militaris & Cordyceps sinensis)

Strong
Mushroom/Fungi

Boosts energy, endurance, and athletic performance by increasing cellular ATP production and improving oxygen utilization.

Cordyceps militaris and Cordyceps sinensis are medicinal fungi containing cordycepin and polysaccharides that enhance cellular energy production throu...

#2
Brown Rice

Brown Rice

Strong
Ancient Grains

Brown rice supports heart health with its high fiber content, which helps lower cholesterol levels and reduce the risk of heart disease. Fiber also aids in maintaining a healthy digestive system by promoting regular bowel movements. - It helps maintain healthy blood sugar levels due to its low glycemic index, making it a suitable choice for diabetics. This slow release of energy helps prevent spikes in blood sugar. - Brown rice is rich in manganese, a mineral that aids in bone health and metabolism. Manganese also plays a role in the production of collagen, which is essential for skin health. - It contains selenium, which supports thyroid function and boosts the immune system by reducing inflammation. - The presence of antioxidants in brown rice helps protect cells from oxidative stress, potentially lowering the risk of chronic diseases. - Brown rice is a good source of magnesium, which is important for muscle and nerve function, as well as maintaining a steady heartbeat. - It provides essential B vitamins that support energy production and brain health, enhancing cognitive function.

Brown rice contains high levels of dietary fiber, magnesium, and phenolic compounds that support cardiovascular health and glucose regulation. The fib...

#3
Miso Paste

Miso Paste

Strong
Fermented/Probiotic

Miso paste supports gut health due to its high probiotic content, enhancing digestion and nutrient absorption. - It enhances immune function with antioxidants, helping to ward off infections. - Miso may reduce the risk of certain cancers, with studies showing a 20% decrease in breast cancer risk. - It is a source of essential minerals like zinc and manganese, crucial for metabolic processes. - The fermentation process in miso contributes to a healthy gut microbiome, improving overall health. - Miso can help lower blood pressure, supporting cardiovascular health. - It is rich in B vitamins, which are vital for energy production and brain health.

Miso paste contains beneficial bacteria (Lactobacillus and Bifidobacterium) and isoflavones that support digestive health through gut microbiome modul...

#4
Liposomal Vitamin C

Liposomal Vitamin C

Strong
Vitamin

Boosts immune system function by enhancing the production of white blood cells, crucial for fighting infections. - Acts as a powerful antioxidant, reducing oxidative stress by up to 40% and protecting cellular integrity. - Enhances skin health by promoting collagen production, leading to firmer and more youthful skin. - Supports cardiovascular health by improving endothelial function and reducing blood pressure. - Increases iron absorption, aiding in the prevention of iron deficiency anemia. - Promotes brain health by protecting against neurodegenerative diseases and enhancing cognitive performance. - Supports adrenal health, helping to manage stress and improve energy levels.

Liposomal vitamin C encapsulates ascorbic acid in phospholipid vesicles, increasing bioavailability by up to 50% compared to standard vitamin C. This ...

#5
Toquilla Palm Nut

Toquilla Palm Nut

Strong
Seed

Enhances energy metabolism: via a rich profile of healthy fats and micronutrients.

Toquilla Palm Nut (Carludovica palmata) is a lipid-rich seed containing tocopherols, tocotrienols, plant sterols, and unsaturated fatty acids that act...

#6
Pectin

Pectin

Strong
Fermented/Probiotic

Supports digestive health by forming a gel-like substance that aids bowel regularity. This ensures smooth and consistent digestion. - Helps lower cholesterol levels by binding to bile acids, reducing cholesterol absorption by up to 10%. This promotes cardiovascular health. - Regulates blood sugar levels by slowing glucose absorption. This helps prevent spikes and crashes in energy. - Enhances satiety, reducing overall calorie intake. This aids in weight management and prevents overeating. - Acts as a prebiotic, feeding beneficial gut bacteria. This supports a balanced and healthy microbiome. - Reduces the risk of colon cancer by increasing short-chain fatty acid production. This maintains colon health and reduces inflammation. - Supports skin health by promoting hydration and elasticity. This results in a more youthful appearance.

Pectin is a soluble fiber and prebiotic compound that forms viscous gels in the digestive tract, slowing nutrient absorption and promoting beneficial ...

#7
Tru Niagen (Nicotinamide Riboside)

Tru Niagen (Nicotinamide Riboside)

Strong
Other

Boosts NAD+ levels, enhancing cellular energy production and reducing fatigue. - Supports healthy aging by promoting DNA repair and cellular resilience, contributing to longevity. - Enhances cognitive function by improving brain energy metabolism, supporting memory and focus. - Supports cardiovascular health by improving blood vessel function and reducing oxidative stress. - Promotes metabolic health by enhancing insulin sensitivity, aiding in weight management. - Reduces inflammation by modulating immune response, contributing to joint and systemic health. - Improves muscle health by enhancing mitochondrial function, supporting endurance and recovery.

Tru Niagen contains nicotinamide riboside chloride, a vitamin B3 derivative that serves as a precursor to NAD+ (nicotinamide adenine dinucleotide). It...

#8
Trametes versicolor dual extract

Trametes versicolor dual extract

Strong
Mushroom/Fungi

Supports immune function by enhancing T-cell activity, crucial for defending against pathogens. Clinical trials show a 40% increase in T-cell response. - Provides anti-cancer properties by inducing apoptosis in cancer cells, offering a natural adjunct to traditional therapies. - Reduces inflammation by modulating cytokine production, which is vital for chronic disease management. - Enhances gut health by promoting beneficial gut bacteria, improving digestion and nutrient absorption. - Acts as a powerful antioxidant, protecting cells from oxidative damage and slowing aging. - Supports cardiovascular health by lowering cholesterol levels, reducing the risk of heart disease. - Boosts energy levels by improving mitochondrial function, leading to increased stamina and vitality.

Trametes versicolor dual extract contains polysaccharopeptide (PSP) and polysaccharide-K (PSK) that modulate immune function through β-glucan activati...

#9
Coffee Tree Fruit

Coffee Tree Fruit

Strong
Fruit

Boosts sustained energy: levels without the jitters associated with isolated caffeine.

Coffee tree fruit (coffee cherry) is rich in chlorogenic acids—comprising up to 80% of total phenolic content—and caffeine, which together provide neu...

#10
Vitamin B12 (Methylcobalamin)

Vitamin B12 (Methylcobalamin)

Strong
Vitamin

Supports brain health and cognitive function by aiding neurotransmitter synthesis. This can enhance memory and concentration, crucial for mental tasks. - Aids in the production of red blood cells, ensuring efficient oxygen delivery. This supports physical endurance and reduces fatigue. - Enhances mood regulation by participating in serotonin production. This can help alleviate mood swings and promote emotional stability. - Supports nerve health by maintaining the myelin sheath. This protection is vital for preventing nerve damage and ensuring proper signal transmission. - Boosts energy levels by converting food into usable energy. This helps combat tiredness and supports active lifestyles. - Supports cardiovascular health by lowering homocysteine levels. This reduction is linked to a lower risk of heart-related issues. - Enhances metabolic function by participating in DNA synthesis. This supports cell growth and repair, promoting overall vitality.

Methylcobalamin is the active form of vitamin B12 that serves as a cofactor for methionine synthase and methylmalonyl-CoA mutase enzymes. It directly ...

#11
Cherimoya

Cherimoya

Strong
Fruit

Boosts collagen production and skin elasticity due to its vitamin C content, contributing to skin vitality.

Cherimoya (Annona cherimola) contains potent bioactive compounds including proanthocyanidins, acetogenin bullatacin, and alkaloids that demonstrate si...

#12
Maitake D-Fraction

Maitake D-Fraction

Strong
Mushroom/Fungi

Enhances immune function by activating macrophages and T-cells, improving pathogen defense. - Supports blood sugar regulation by enhancing insulin sensitivity, aiding in diabetes management. - Exhibits anti-cancer properties by inhibiting tumor growth, contributing to cancer prevention. - Promotes cardiovascular health by reducing cholesterol levels, supporting heart wellness. - Reduces inflammation by modulating cytokine production, aiding in chronic disease management. - Supports liver health by enhancing detoxification processes, promoting overall liver function. - Boosts energy levels by improving cellular metabolism, reducing fatigue.

Maitake D-Fraction is a standardized beta-glucan extract from Grifola frondosa mushrooms containing 1,3/1,6-beta-D-glucan as the primary bioactive com...

#13
Kava Leaf

Kava Leaf

Strong
Leaf/Green

Supports stress relief, immune resilience, cardiovascular health, digestive wellness, and respiratory support. Rich in antioxidants, calming compounds, and essential minerals. Research further indicates that Kava Leaf may support metabolic efficiency and cellular energy production through its micronutrient and cofactor content. The synergistic interaction between its primary bioactives contributes to comprehensive antioxidant defense, immune vigilance, and tissue repair mechanisms, making it a valuable functional food ingredient.

Kava leaf contains kavalactones that modulate GABA neurotransmitter activity in the brain, producing anxiolytic and stress-reducing effects. The prima...

#14
Egg White Protein

Egg White Protein

Strong
Protein

Supports muscle growth and repair by providing high-quality protein, essential for muscle synthesis. This can enhance muscle recovery by up to 50% post-exercise. - Promotes weight management by providing satiety, reducing overall calorie intake. - Enhances athletic performance with its rich amino acid profile, crucial for energy production and endurance. - Supports metabolic health by aiding in the regulation of blood sugar levels. - Boosts immune function by supplying essential amino acids that support antibody production. - Improves skin health by providing proteins that support collagen synthesis, enhancing skin firmness. - Aids in maintaining cardiovascular health by supporting healthy cholesterol levels.

Egg white protein contains all nine essential amino acids in optimal ratios, making it a complete protein with the highest biological value of 100. It...

#15
Slippery Elm Bark

Slippery Elm Bark

Strong
Bark

Promotes skin vitality: and wound healing when applied topically, due to its soothing and protective qualities.

Slippery elm bark (Ulmus rubra) contains 50–60% mucilage composed of mucopolysaccharides—including hexose, pentose, methylpentose, and galacturonic ac...

#16
Hydroxocobalamin (B12)

Hydroxocobalamin (B12)

Strong
Vitamin

Enhances red blood cell formation, crucial for preventing anemia and maintaining energy levels. - Supports nerve health by aiding in myelin sheath formation, protecting nerves from damage. - Boosts cognitive function by improving brain health and reducing the risk of neurodegenerative diseases. - Aids in the detoxification of cyanide, a harmful compound, by converting it into less toxic substances. - Improves sleep patterns by regulating melatonin production, promoting restful sleep. - Supports cardiovascular health by reducing homocysteine levels, lowering the risk of heart disease. - Enhances mood and mental clarity by supporting neurotransmitter synthesis, reducing symptoms of depression.

Hydroxocobalamin is a vitamin B12 form that serves as a precursor to methylcobalamin and adenosylcobalamin, the active coenzymes. It functions as a co...

#17
Hydroxocobalamin

Hydroxocobalamin

Strong
Vitamin

Supports red blood cell production, preventing anemia and ensuring efficient oxygen delivery throughout the body. - Enhances cognitive function and neurological health by supporting neurotransmitter synthesis and protecting nerve cells. - Detoxifies cyanide, a harmful compound, by converting it into a less toxic form, which is crucial for individuals exposed to cyanide. - Boosts immune function by supporting the production of white blood cells, which are essential for fighting infections. - Improves cardiovascular health by reducing homocysteine levels, which is associated with a lower risk of heart diseases. - Supports skin health by promoting collagen synthesis, which can improve skin elasticity and reduce wrinkles. - Aids in energy production by participating in the conversion of food into energy, which is vital for maintaining vitality.

Hydroxocobalamin is the natural, injectable form of vitamin B12 that serves as a direct precursor to the active coenzymes methylcobalamin and adenosyl...

#18
Vitamin B12 (Intranasal)

Vitamin B12 (Intranasal)

Strong
Vitamin

Provides efficient energy production by facilitating the conversion of food into energy. This direct absorption method ensures immediate effects. - Supports cognitive health by enhancing neurotransmitter function, leading to improved focus and memory retention. This is vital for maintaining mental acuity. - Promotes cardiovascular health by reducing homocysteine levels, which are linked to heart disease. This helps in maintaining a healthy circulatory system. - Enhances mood and mental well-being by supporting serotonin production, which can alleviate symptoms of depression. This leads to a more balanced emotional state. - Boosts immune function by aiding in the production of white blood cells, crucial for fighting infections. This strengthens the body's defense mechanisms. - Supports red blood cell production, preventing anemia and ensuring adequate oxygen supply to tissues. This is essential for maintaining overall vitality. - Improves skin health by promoting cell regeneration, leading to a healthier and more vibrant complexion.

Intranasal vitamin B12 delivers cobalamin directly through nasal mucosa, bypassing gastrointestinal absorption barriers. This method provides rapid bi...

#19
Bush Mango Seed

Bush Mango Seed

Strong
Seed

Regulates metabolism, contributing to healthy weight management and energy balance.

Bush Mango Seed (Irvingia gabonensis) contains potent phenolic compounds including gallic acid, caffeic acid, and pentagalloylglucose that demonstrate...

#20
Arrowroot Tubers

Arrowroot Tubers

Strong
Vegetable

Delivers an energy boost: Offers a quick, sustainable source of energy through complex carbohydrates.

Arrowroot tubers contain 4580 mg GAE/100g of phenolic compounds including quercetin and kaempferol derivatives that provide antioxidant and anti-infla...