Herbs (Global Traditional) · European
Chasteberry (Vitex agnus-castus)
Strong Evidencebotanical
Hermetica Superfood Encyclopedia
Chasteberry (Vitex agnus-castus) contains diterpenes and flavonoids that interact with dopamine D2 receptors in the pituitary gland, influencing prolactin secretion. This Mediterranean herb has been traditionally used for hormonal balance, though clinical evidence remains limited to preliminary studies.
Chasteberry (Vitex agnus-castus) is a shrub native to the Mediterranean region and western Asia, belonging to the Verbenaceae family, with fruits and leaves used medicinally. Extracts are derived from small drupes (berries) using methods including methanol extraction, vacuum liquid chromatography, and steam distillation for essential oils.
The current research dossier lacks human clinical trials, randomized controlled trials, or meta-analyses for chasteberry. Available evidence is limited to in vitro bioassays showing cholinesterase inhibition (IC50 786.16 μg/mL for AChE and 133.54 μg/mL for BChE) and chemical composition analyses.
No clinically studied dosage ranges are available from human trials. Standardization protocols for extracts have not been established in the provided research. Consult a healthcare provider before starting any new supplement.
Chasteberry (Vitex agnus-castus) fruit and leaf composition is characterized primarily by bioactive secondary metabolites rather than significant macronutrient content. Macronutrients: minimal caloric contribution in therapeutic doses; crude fiber present in whole berry preparations. Key bioactive compounds include iridoid glycosides — agnuside (0.3–0.6% dry weight) and aucubin (0.4–0.9% dry weight) — which are considered primary marker compounds for standardized extracts. Flavonoids are abundant, with casticin (vitexicarpin) at approximately 0.1–0.5% dry weight serving as a dominant flavone; additional flavonoids include penduletin, chrysosplenol-D, luteolin, and apigenin at trace to minor concentrations (0.01–0.1% range). Diterpenes include clerodadienols (e.g., rotundifuran, vitexilactone) relevant to dopaminergic activity. Essential oils constitute approximately 0.5–1.5% of dried fruit, containing 1,8-cineole, limonene, beta-caryophyllene, and sabinene. Phenolic acids include caffeic acid and hydroxycinnamic acid derivatives at low concentrations (<0.1% dry weight). Fatty acids present in seed fraction include linoleic and oleic acids. Mineral content is not well-characterized but includes trace potassium, calcium, and magnesium. Bioavailability: iridoid glycosides show moderate oral absorption; flavonoid bioavailability is limited by hepatic first-pass metabolism and requires phase II conjugation; lipophilic diterpenes may benefit from fat co-ingestion. Standardized commercial extracts are typically normalized to 0.5% agnuside or 0.6% casticin.
Chasteberry's primary bioactive compounds, including diterpenes like rotundifuran and clerodadienols, act as selective dopamine D2 receptor agonists in the anterior pituitary. This dopaminergic activity inhibits prolactin secretion while potentially modulating luteinizing hormone release. The herb's flavonoids, particularly casticin and vitexin, contribute additional antioxidant effects through free radical scavenging mechanisms.
Most research on chasteberry consists of small-scale studies and traditional use reports rather than large randomized controlled trials. In vitro studies have demonstrated cholinesterase inhibition activity, but this has not been validated in human clinical trials. Chemical analyses confirm high concentrations of antioxidant compounds including flavonoids and phenolic acids, though clinical outcomes related to oxidative stress have not been systematically studied. The evidence base remains preliminary and requires larger, well-designed human studies for definitive health claims.
Chasteberry is generally well-tolerated but may cause gastrointestinal upset, headaches, or skin reactions in some individuals. The herb can interact with hormonal medications, including birth control pills and hormone replacement therapy, potentially reducing their effectiveness. It may also interact with dopamine agonists and antagonists used for Parkinson's disease or psychiatric conditions. Pregnant and breastfeeding women should avoid chasteberry due to its hormonal effects and lack of safety data in these populations.
