Named Bioactive Compounds · Compound
Centaurin
Moderate Evidenceflavone1 PubMed Study
Hermetica Superfood Encyclopedia
Centaurin is a flavone compound that modulates centaurin-α1 protein expression, potentially affecting neuroinflammatory pathways. Research suggests it may influence cognitive function and autoimmune responses in the central nervous system through GTPase-activating protein regulation.
Centaurins are endogenous ADP-ribosylation factor GTPase-activating proteins (Arf-GAPs) produced naturally by mammalian cells, particularly neurons in the brain and other tissues. These proteins exist in multiple isoforms (centaurin-α1, centaurin-α2, centaurin-γ3) and function as intracellular signaling molecules rather than being extracted from plants or organisms.
No human clinical trials, RCTs, or meta-analyses exist for centaurin as a therapeutic agent or supplement. All available evidence comes from preclinical research using animal models (J20 transgenic mice) and cell culture systems, with no PubMed PMIDs for human trials available.
No clinically studied dosage ranges exist as centaurin has never been tested in humans as a therapeutic or supplement. Current research uses genetic knockout models or cellular overexpression rather than administered doses. Consult a healthcare provider before starting any new supplement.
Centaurin is not a nutrient, food, or dietary supplement — it is a family of intracellular signaling proteins (also known as centaurin-alpha, ADAP1/centaurin-α1, and related isoforms) that function as ArfGAPs (ADP-ribosylation factor GTPase-activating proteins) and phosphatidylinositol 3,4,5-trisphosphate (PIP3) binding proteins endogenously expressed in mammalian tissues, particularly enriched in brain neurons. As an endogenous protein, it has no conventional nutritional profile — no macronutrient, micronutrient, vitamin, mineral, or fiber content applies. It is not consumed as a food or supplement. Bioactive context: Centaurin-α1 (ADAP1) contains a zinc-finger ArfGAP domain and a pleckstrin homology (PH) domain with high-affinity binding for PIP3 (Kd ~50 nM). It modulates Arf6-dependent membrane trafficking, dendritic branching, and synaptic plasticity. Centaurin-α2 (CENTG1/AGAP1) and centaurin-γ (AGAP2/PIKE) are related family members with distinct domain architectures. These proteins are not bioavailable via oral ingestion and cannot be obtained through diet. No known food source, dietary precursor, or supplemental form exists. Any referenced biological effects (neuroprotection, anti-inflammatory activity) derive from genetic modulation studies in animal models, not from exogenous administration or nutritional intake.
Centaurin appears to work by modulating centaurin-α1 protein expression, which functions as a GTPase-activating protein in neuronal signaling pathways. The deletion or reduction of centaurin-α1 may alter Arf family GTPase activity, potentially reducing neuroinflammatory responses and improving synaptic function. This mechanism involves the regulation of vesicular trafficking and membrane dynamics in neural cells.
Current evidence for centaurin is limited to preliminary animal studies using transgenic mouse models. Research on J20 transgenic mice showed improved cognitive function when centaurin-α1 was deleted, suggesting potential benefits for Alzheimer's disease progression. Additional studies in centaurin-α1 deficient mice demonstrated partial resistance to experimental autoimmune encephalomyelitis, indicating possible neuroinflammatory protection. No human clinical trials or safety data are currently available for centaurin supplementation.
Safety data for centaurin supplementation is not available due to lack of human studies. The compound's effects on GTPase signaling pathways suggest potential interactions with medications affecting neurological function or immune responses. Given the preliminary nature of research and unknown effects on human physiology, centaurin should be avoided during pregnancy and breastfeeding. Individuals with neurological conditions or those taking immunosuppressive medications should consult healthcare providers before considering use.
