Cannabichromene

Cannabichromene (CBC) is a non-psychoactive phytocannabinoid, not a conventional nutritional ingredient and therefore contains no meaningful macronutrients (0g protein, 0g fat, 0g carbohydrates per typical isolate dose), no dietary fiber, and no classical vitamins or minerals. It is a bioactive compound classified as a terpenophenolic molecule with molecular formula C21H30O2 and molecular weight of 314.46 g/mol. CBC is typically found in Cannabis sativa L. plant material at concentrations of 0.1–1.0% dry weight, generally lower than THC or CBD in most cultivars, though some hemp chemotypes yield up to 3–4% CBC by dry weight. As an isolated compound, it is administered in experimental or supplement contexts at doses ranging from 5–50mg per serving in commercial preparations. Bioavailability: CBC is highly lipophilic (logP estimated ~6), resulting in poor aqueous solubility and low oral bioavailability when unformulated; lipid-based delivery systems, nanoemulsions, or sublingual administration significantly enhance absorption. It undergoes first-pass hepatic metabolism via CYP450 enzymes (primarily CYP3A4 and CYP2C9), producing hydroxylated metabolites. No caloric value is attributed to CBC at pharmacologically relevant doses. It does not contribute to recommended daily intake of any nutrient. Primary bioactive relevance is its interaction with TRPA1 and TRPV4 channels, and indirect endocannabinoid tone elevation rather than any nutritional function.