Hermetica Superfood Encyclopedia
The Short Answer
Ashitaba Chalcone Extract contains standardized concentrations of 4-hydroxyderricin and xanthoangelol, two chalcone compounds that activate AMPK pathways and hepatic FXR signaling to support metabolic function. These bioactive chalcones demonstrate anti-inflammatory effects through TNF-α inhibition and promote fatty acid oxidation while reducing bile acid synthesis.
CategoryLeaf & Herb
GroupExtract
Evidence LevelStrong
Primary Keywordashitaba chalcone extract benefits
Synergy Pairings4
Ashitaba Chalcone Extract — botanical close-up
Health Benefits
Provides potent antioxidant protection via chalcones, neutralizing free radicals and reducing oxidative stress.
Exhibits significant anti-inflammatory properties, supporting cellular health and reducing systemic inflammation.
Stimulates cellular regeneration and supports DNA repair, contributing to overall longevity.
Enhances metabolic function, potentially aiding in blood sugar regulation
Offers neuroprotective benefits, supporting brain health and cognitive function
Origin & History
Natural habitat
Ashitaba Chalcone Extract is derived from the stems and leaves of Angelica keiskei, a plant native to Japan, particularly the Izu Islands. This concentrated extract isolates the unique chalcone compounds, offering targeted functional benefits for cellular health and metabolism.
“While Ashitaba itself has a long history in traditional Japanese medicine, Ashitaba Chalcone Extract is a modern concentrated isolate. Its value stems from traditional knowledge of the whole plant, with modern science isolating and validating the specific chalcone compounds for targeted benefits.”Traditional Medicine
Scientific Research
Research focuses on the isolated chalcone compounds, particularly xanthoangelol and 4-hydroxyderricin, demonstrating their potent antioxidant, anti-inflammatory, and metabolic-supportive effects in in vitro and animal studies. Further human clinical trials are exploring their full therapeutic potential.
Preparation & Dosage
Traditional preparation
Common forms
Liquid extract, capsules, powder.
Dosage
1-2 ml liquid extract daily; 500 mg capsules once or twice daily with meals; 1 tsp powder in smoothies or juices
Timing
Best taken with meals for optimal absorption.
Nutritional Profile
- Chalcones: Xanthoangelol, 4-Hydroxyderricin (potent anti-inflammatory, antioxidant, and metabolic agents)
- Vitamins: B12 (essential for energy production and nervous system function)
- Polyphenols: (reduce oxidative stress and support cardiovascular health)
How It Works
Mechanism of Action
The primary chalcones 4-hydroxyderricin and xanthoangelol activate AMPK pathways, inactivating acetyl-CoA carboxylase to promote fatty acid oxidation via CPT-1A. These compounds upregulate adiponectin mRNA expression up to 8.27-fold and activate hepatic FXR signaling, which represses CYP7A1 by 38.8% and SCD-1 by 43.8% to inhibit bile acid synthesis and de novo fatty acid production. Anti-inflammatory effects occur through TNF-α inhibition and apoptosis induction in abnormal cells.
Clinical Evidence
Human clinical trials have demonstrated anti-obesity effects in both men and women, though specific weight loss percentages were not quantified in available studies. Preclinical studies in high-fat diet mouse models showed FXR expression increased 1.58-fold with corresponding reductions in CYP7A1 and SCD-1 enzymes. Safety studies in mice confirmed safe absorption of both primary chalcones at doses up to 1000 mg/kg daily for three days without adverse effects. Current evidence is primarily from animal studies with limited human clinical data available.
Safety & Interactions
High-dose studies in rats (1000 mg/kg/day) showed significant increases in serum alkaline phosphatase, total cholesterol, phospholipids, and triglycerides, with some animals developing jejunal lymphangiectasia. Elevated AST levels occurred in high-dose female subjects, though the clinical significance remains unclear. No genotoxicity was observed in chromosomal aberration tests, and no drug interactions or contraindications have been specifically identified in current research. Pregnant and nursing women should avoid use due to insufficient safety data in these populations.
Synergy Stack
Hermetica Formulation Heuristic
Polyphenol/antioxidant base
Immune & Inflammation | Longevity & Anti-Aging
Also Known As
Angelica keiskei extractAshitaba-chalconeChalcone ashitabaA. keiskei chalcone standardized extract
Frequently Asked Questions
What are the main active compounds in Ashitaba Chalcone Extract?
The primary bioactive compounds are 4-hydroxyderricin and xanthoangelol, two chalcone compounds that are the most abundant in Ashitaba. These compounds are responsible for the extract's anti-inflammatory, antioxidant, and metabolic effects through AMPK activation and FXR signaling pathways.
How does Ashitaba Chalcone Extract support weight management?
The chalcones activate AMPK pathways that promote fatty acid oxidation via CPT-1A while reducing de novo fatty acid synthesis. Clinical studies show anti-obesity effects in humans, and animal studies demonstrate prevention of adiposity through hepatic FXR signaling that reduces fat-producing enzymes by up to 43.8%.
What is the recommended dosage for Ashitaba Chalcone Extract?
Specific human dosage recommendations are not well-established due to limited clinical trials. Animal safety studies used doses up to 1000 mg/kg daily, but human studies have not provided standardized dosing protocols. Consultation with a healthcare provider is recommended for appropriate dosing.
Are there any side effects from taking Ashitaba Chalcone Extract?
High-dose animal studies (1000 mg/kg/day) showed increases in liver enzymes, cholesterol, and triglycerides, with some developing intestinal lymphangiectasia. However, lower doses in mice showed no adverse effects, and no genotoxicity was observed in safety testing.
How long does it take to see results from Ashitaba Chalcone Extract?
Specific timeframes for therapeutic effects have not been established in human clinical trials. Animal studies show metabolic changes within the study periods, but individual response times in humans likely vary based on dosage, individual metabolism, and health status. More human research is needed to determine optimal treatment duration.
Does Ashitaba Chalcone Extract interact with diabetes medications or blood sugar regulators?
Ashitaba Chalcone Extract may enhance blood sugar regulation, which could potentiate the effects of diabetes medications like metformin or insulin. If you are taking blood sugar-lowering medications, consult your healthcare provider before supplementing, as dose adjustments may be necessary to avoid hypoglycemia. Monitoring blood glucose levels is recommended when combining this ingredient with prescription antidiabetic drugs.
Is Ashitaba Chalcone Extract safe during pregnancy and breastfeeding?
There is insufficient clinical evidence regarding the safety of Ashitaba Chalcone Extract during pregnancy and breastfeeding, so it is not recommended during these periods. Pregnant and nursing women should consult their healthcare provider before using this ingredient, as its effects on fetal development and milk composition have not been adequately studied. It is best to err on the side of caution during these sensitive life stages.
What clinical research supports the antioxidant and anti-inflammatory benefits of Ashitaba Chalcone Extract?
In vitro and animal studies have demonstrated that ashitaba chalcones, particularly xanthoangelol and decursinol, exhibit potent free radical scavenging and inflammatory cytokine suppression. However, human clinical trials specifically examining Ashitaba Chalcone Extract are limited, with most evidence derived from traditional use and laboratory research rather than large-scale randomized controlled trials. More robust human studies are needed to confirm efficacy and establish optimal dosing for longevity and cellular health benefits.
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