AHCC (Active Hexose Correlated Compound)

AHCC is a standardized extract derived primarily from Lentinula edodes (shiitake) mushroom mycelia, cultured in rice bran (koji). Its primary bioactive constituents are partially acetylated alpha-1,4-glucans (oligosaccharides), with alpha-glucans comprising approximately 20% of dry weight — notably distinct from the beta-glucans found in most mushroom extracts, which contributes to its unique immunomodulatory profile. Molecular weight of the active oligosaccharides is approximately 5,000 Da, significantly smaller than native polysaccharides, enhancing oral bioavailability and intestinal absorption. Additional components include: polysaccharides (total ~40% dry weight), amino acids including glutamine, alanine, and aspartic acid (~10-15% dry weight), lipids (~1-3%), minerals including potassium (~180 mg/100g), calcium (~30 mg/100g), magnesium (~20 mg/100g), and trace zinc and selenium. Contains small amounts of ergosterol (provitamin D2 precursor, ~2-5 mg/100g). Fiber content is moderate (~15-20% dry weight). Protein content is approximately 8-12% dry weight. Standard commercial dosing is 500 mg–3 g/day; at 1 g, approximately 200 mg of active alpha-glucan fraction is delivered. Bioavailability is notably higher than crude mushroom polysaccharides due to low molecular weight fractionation during enzymatic culturing process.