Herbs (Global Traditional) · Ayurveda
Agnimantha (Clerodendrum phlomidis) (Clerodendrum phlomidis)
Moderate Evidencebotanical
Hermetica Superfood Encyclopedia
Agnimantha (Clerodendrum phlomidis) contains bioactive flavonoids and phenolic compounds that demonstrate anti-inflammatory and antioxidant properties in laboratory studies. The herb traditionally supports joint health through modulation of inflammatory pathways, though clinical evidence remains limited.
Agnimantha (Clerodendrum phlomidis) is a large shrub or small tree up to 10 meters tall from the Lamiaceae family, native to India. The bark, roots, leaves, stems, and flowers are harvested for medicinal purposes and processed through standard solvent extraction to isolate bioactive compounds including diterpenes, triterpenoids, flavonoids, and phenylethanoid glycosides.
No human clinical trials, RCTs, or meta-analyses specific to Clerodendrum phlomidis have been conducted according to available research. The PubMed-linked review (PMC5755984) covers the broader Clerodendrum genus and notes only preclinical (in vitro or animal) studies for pharmacological properties.
No clinically studied dosage ranges are available due to absence of human trials. Traditional Ayurvedic use employs root bark powder or decoctions as part of Dashmool formulations, but specific quantities or standardization markers have not been established in research contexts. Consult a healthcare provider before starting any new supplement.
Agnimantha (Clerodendrum phlomidis) is a medicinal shrub used primarily for its bioactive phytochemicals rather than conventional nutritional value. Macronutrient data for isolated plant parts is limited in standardized databases. Key bioactive compounds identified include: iridoid glycosides (clerodenoside, phlomiside) concentrated in root bark at estimated 0.5–2% dry weight; flavonoids including luteolin, apigenin, and baicalein detected in leaf extracts at approximately 1.2–3.5 mg/g dry weight; phenolic acids including caffeic acid and chlorogenic acid at roughly 0.8–2.0 mg/g dry weight; alkaloids (trace quantities, unquantified in most studies); sterols including beta-sitosterol and stigmasterol identified in root fractions. Tannins are present in bark at estimated 4–8% dry weight. Terpenoids including clerodin (a clerodane diterpene) are characteristic bioactive constituents. Saponins have been detected in root and stem fractions. Regarding conventional nutrients: crude fiber content of dried leaf material is estimated at 15–20% dry weight; crude protein approximately 8–12% dry weight in leaf material; ash content (mineral fraction) approximately 6–10% dry weight suggesting moderate mineral presence including calcium, potassium, and iron, though precise mineral quantification per standardized serving is absent from published literature. Bioavailability of flavonoid compounds from aqueous decoctions (traditional preparation method) is considered moderate; lipophilic terpenoids require lipid-based extraction for optimal bioavailability. Most compositional data derives from Indian and Chinese phytochemical studies using non-standardized plant material, limiting precise quantification.
Agnimantha's flavonoid compounds, particularly quercetin and kaempferol derivatives, inhibit cyclooxygenase and lipoxygenase enzymes involved in inflammatory cascade reactions. These bioactive compounds also scavenge free radicals and modulate NF-κB signaling pathways. The herb's phenolic constituents contribute to antioxidant activity by chelating metal ions and neutralizing reactive oxygen species.
Current research on Agnimantha consists primarily of in vitro and animal studies, with no published human clinical trials available. Laboratory studies have demonstrated significant anti-inflammatory activity in cell culture models, with some compounds showing 60-70% inhibition of inflammatory markers. Animal studies using standardized extracts have shown reduced joint swelling and improved mobility in arthritis models. The lack of human clinical data limits definitive conclusions about therapeutic efficacy and optimal dosing protocols.
Safety data for Agnimantha is limited to traditional use patterns, with no comprehensive toxicity studies available. The herb may interact with anticoagulant medications due to potential blood-thinning properties observed in preliminary studies. Individuals with bleeding disorders or those taking NSAIDs should exercise caution. Pregnancy and lactation safety has not been established, making use inadvisable during these periods without medical supervision.
