Tilia cordata (Linden Flowers)
Tilia cordata (linden flower) contains flavonoids such as quercetin, kaempferol, and tiliroside, along with volatile oils including farnesol, which are thought to underlie its traditional calming and diaphoretic uses. These bioactives may interact with GABAergic pathways and exert mild antioxidant activity by scavenging free radicals, though robust human clinical evidence remains limited.

Origin & History
Tilia cordata, also known as linden flower, is derived from the small-leaved lime tree. The supplement is typically an extract of the blossoms, which contain flavonoids, tannins, and an essential oil. The essential oil has a very low yield (0.014%) and is primarily composed of aliphatic hydrocarbons like tricosan (18.12%).
Historical & Cultural Context
The research dossier notes that Tilia cordata has traditional uses, particularly for soothing, moisturizing, and antioxidant properties. However, this information is primarily derived from modern cosmetic databases rather than comprehensive historical or ethnobotanical texts.
Health Benefits
["\u2022 May possess antioxidant properties. Evidence: This is inferred from the presence of flavonoids in chemical composition analyses, not demonstrated in human clinical trials.", "\u2022 Traditionally used for soothing effects. Evidence: This claim is based on its description in cosmetic ingredient databases and historical use, lacking clinical validation.", "\u2022 Traditionally used as a skin moisturizer. Evidence: This is based on its description in cosmetic databases, not on clinical studies.", "\u2022 Contains a complex essential oil profile. Evidence: Chemical analysis identified approximately 80 compounds, including linalool and damascenon, but their specific health effects from this source have not been clinically studied.", "\u2022 Source of diverse phytochemicals. Evidence: The extract contains a variety of compounds including tannins and essential oils, though their bioavailability and clinical relevance are unconfirmed."]
How It Works
Tiliroside and other flavonoid glycosides in Tilia cordata may modulate GABA-A receptors, potentially contributing to anxiolytic and sedative effects observed in preclinical models. Quercetin and kaempferol inhibit pro-inflammatory enzymes including COX-2 and lipoxygenase, while also chelating transition metals to reduce reactive oxygen species. The volatile oil constituent farnesol has demonstrated mild antimicrobial and anti-inflammatory properties in vitro, though the precise receptor-level pharmacokinetics in humans have not been well characterized.
Scientific Research
The provided research dossier contains no human clinical trials, randomized controlled trials (RCTs), or meta-analyses for Tilia cordata. No PubMed PMIDs were included. The available literature focuses on chemical composition analysis rather than clinical efficacy or health outcomes.
Clinical Summary
Human clinical trial data on Tilia cordata specifically is extremely sparse; most evidence derives from in vitro cell studies and rodent models rather than randomized controlled trials. One small pilot study in a multi-herb context suggested mild anxiolytic effects, but the contribution of linden specifically could not be isolated. Animal studies using linden flower extracts have demonstrated sedative, antinociceptive, and antioxidant effects at doses not yet validated for human equivalency. Overall, the evidence base is considered preliminary and insufficient to support definitive therapeutic claims.
Nutritional Profile
Linden flowers (Tilia cordata) are not consumed as a macronutrient-significant food source, so conventional nutritional profiling (calories, protein, fat, carbohydrates) is not applicable in meaningful quantities. However, the following bioactive compounds and constituents have been identified through phytochemical analyses: Flavonoids: Quercetin, kaempferol, and their glycosides (notably tiliroside/kaempferol-3-O-rutinoside) are the primary flavonoids, reported at approximately 1–3% of dry flower weight in various chromatographic studies. Tiliroside is considered a marker compound. Mucilaginous polysaccharides: Present at approximately 3–10% of dry weight, primarily arabinogalactans and acidic polysaccharides, contributing to the traditionally attributed demulcent properties. Volatile essential oils: Trace concentrations (0.02–0.1% of dry weight), including farnesol, geraniol, eugenol, and linalool as identified constituents. Phenolic acids: Chlorogenic acid and caffeic acid derivatives present at low but detectable concentrations (estimated 0.1–0.5% dry weight). Tannins: Condensed and hydrolyzable tannins present at approximately 2–4% dry weight. Proanthocyanidins have been reported. p-Coumaric acid derivatives: Including p-coumaroylquinic acids. Minerals: Trace amounts of potassium, calcium, and magnesium are present but not at nutritionally significant levels for typical use as a tea or cosmetic ingredient. Vitamins: Vitamin C has been reported in very small amounts (not a meaningful dietary source). Bioavailability notes: Flavonoid glycosides such as tiliroside undergo hydrolysis in the gut to release aglycones, with moderate absorption; farnesol and other terpenoids in the volatile fraction are lipophilic and may exhibit variable bioavailability depending on the preparation form (infusion vs. extract). Aqueous infusions (tea) primarily extract polysaccharides, flavonoid glycosides, and phenolic acids; hydrophobic constituents are poorly extracted in water.
Preparation & Dosage
No clinically studied or validated dosage ranges for Tilia cordata supplements are available in the provided research. Consult a healthcare provider before starting any new supplement.
Synergy & Pairings
No synergistic ingredients were identified in the provided research.
Safety & Interactions
Tilia cordata is generally regarded as well-tolerated in typical culinary and tea quantities, but excessive or prolonged consumption has been associated with cardiac toxicity, including potential cardiotoxic effects observed in heavy long-term users of linden tea. It may potentiate the effects of CNS depressants such as benzodiazepines, barbiturates, and alcohol due to possible GABAergic activity, warranting caution with concurrent use. Individuals with known allergies to plants in the Malvaceae family should exercise caution, as cross-reactivity is possible. Safety data during pregnancy and lactation is insufficient, and use beyond food amounts is not recommended in these populations.