Setria (Reduced Glutathione)

Setria is a patented form of reduced glutathione (L-γ-glutamyl-L-cysteinyl-glycine) that directly elevates cellular glutathione levels. It functions as the body's master antioxidant by neutralizing free radicals and supporting phase II detoxification pathways.

Origin & History

Setria is a branded form of reduced glutathione, a powerful antioxidant naturally produced in the body, manufactured through a fermentation process.

Historical & Cultural Context

Glutathione has been recognized for its health benefits in modern medicine, though it lacks a significant historical or cultural usage context.

Health Benefits

- Enhances detoxification by boosting liver function, increasing glutathione levels by 30%. This helps in the removal of toxins and supports liver health. - Strengthens the immune system by supporting white blood cell function, making the body more resilient against infections. This is vital for maintaining overall health. - Improves skin health by reducing oxidative stress, leading to a clearer, more radiant complexion. This can help reduce the appearance of blemishes and aging signs. - Supports respiratory health by reducing inflammation in the airways, which can alleviate symptoms of asthma and improve breathing. - Enhances energy levels by supporting mitochondrial function, leading to improved stamina and reduced fatigue. This is crucial for maintaining an active lifestyle. - Acts as a powerful antioxidant, protecting cells from damage and reducing the risk of chronic diseases. This promotes longevity and overall health. - Supports mental clarity by reducing oxidative stress in the brain, which can enhance focus and cognitive function.

How It Works

Setria provides bioavailable reduced glutathione that directly increases intracellular GSH concentrations. It activates glutathione peroxidase and glutathione S-transferase enzymes, facilitating conjugation of toxins for elimination. The tripeptide also regenerates vitamins C and E while maintaining the reduced state of cysteine residues in proteins.

Scientific Research

Research, including clinical trials, supports Setria's role in enhancing antioxidant capacity and detoxification processes in the body.

Clinical Summary

Human studies demonstrate that Setria supplementation increases blood glutathione levels by 30% within 6 months at 500-1000mg daily doses. A randomized controlled trial with 54 adults showed significant improvements in oxidative stress markers and immune cell function. However, most clinical evidence comes from smaller studies lasting 6 months or less, with limited long-term safety data available.

Nutritional Profile

Setria (Reduced Glutathione) is a tripeptide composed of three amino acids: L-glutamate, L-cysteine, and glycine, with a molecular weight of 307.32 g/mol. As a purified bioactive compound rather than a whole food, it lacks conventional macronutrient or micronutrient profiles. Key compositional data: Protein-equivalent content approximately 85-95% pure reduced glutathione (GSH) per serving, typically dosed at 250-500mg per serving in supplement form. The active thiol (-SH) group on the cysteine residue is the primary bioactive site responsible for antioxidant and detoxification activity. Sulfur content is notably significant due to the cysteine component, contributing to its redox-active properties. Bioavailability notes: Setria is a patented, fermentation-derived form of glutathione clinically demonstrated to resist gastric degradation better than standard glutathione; oral bioavailability studies show blood GSH levels increase by approximately 30-35% at 250mg/day dosing over 4 weeks. Lymphocyte glutathione concentrations have been shown to increase by up to 35% with consistent supplementation. Unlike standard glutathione supplements, Setria has demonstrated measurable increases in whole-blood glutathione in randomized controlled trials, indicating superior absorption compared to non-patented forms. No caloric, fiber, or conventional mineral content of significance.

Preparation & Dosage

Typical dosage ranges from 250 to 1000 mg per day. Consult a healthcare provider before use.

Synergy & Pairings

NAC (N-Acetylcysteine), Alpha Lipoic Acid, Vitamin C

Safety & Interactions

Setria is generally well-tolerated with minimal side effects reported at standard doses up to 1000mg daily. Some individuals may experience mild gastrointestinal upset, particularly on empty stomach. It may enhance the effects of chemotherapy drugs and should be used cautiously with immunosuppressive medications. Safety during pregnancy and breastfeeding has not been established in clinical trials.