Neurophenol (Vitis vinifera/Camellia sinensis extract)

Neurophenol is a standardized extract combining grape (Vitis vinifera) and green tea (Camellia sinensis) polyphenols designed for cognitive enhancement. The blend provides catechins and resveratrol that support neuroplasticity and cognitive processing speed through antioxidant and neuroprotective mechanisms.

Origin & History

Neurophenol is a branded polyphenol-rich nutraceutical extract derived from Vitis vinifera (grape) and Camellia sinensis (green tea), belonging to the polyphenol class of compounds. While the specific proprietary extraction methods are not detailed in available studies, these plants are typically processed through solvent extraction or water-based methods to concentrate bioactive polyphenols including flavonoids and catechins.

Historical & Cultural Context

No historical or traditional medicine context is provided for Neurophenol as it is a modern branded extract. While the parent plants (Vitis vinifera and Camellia sinensis) have long histories in European and Asian traditions for their antioxidant properties, they were not traditionally used in this specific combination.

Health Benefits

• Improved cognitive processing speed: Significant improvements in Stroop Test scores (p<0.001 vs placebo) in a randomized controlled trial
• Enhanced intellectual performance: Significant increase in Reynolds Intellectual Screening Test (RIST) scores (p<0.01) based on clinical evidence
• Elevated brain-derived neurotrophic factor (BDNF): Plasma levels increased to 7.16±1.46 ng/mL (p<0.05), correlating with cognitive benefits (r=0.63, p<0.001)
• Increased CREB protein levels: Plasma CREB elevated to 1.49±0.28 ng/mL (p<0.05), supporting neuroprotective pathways
• Improved execution speed: Significant enhancement in task execution speed (p<0.05) demonstrated in controlled trial

How It Works

Neurophenol's catechins from green tea and resveratrol from grape extract cross the blood-brain barrier to modulate BDNF (brain-derived neurotrophic factor) expression and enhance synaptic plasticity. These polyphenolic compounds activate CREB signaling pathways and provide neuroprotection through antioxidant activity, reducing oxidative stress in neural tissues. The synergistic action supports neurotransmitter function and cognitive processing efficiency.

Scientific Research

One randomized, placebo-controlled crossover trial (registered as CFE/JU/44-17, ethical approval November 2017) evaluated Neurophenol's impact on cognitive function in healthy adults, showing significant improvements in multiple cognitive assessments and biomarkers. No PubMed PMID is available for this trial, and the sample size was not explicitly stated in the available research. No other RCTs, meta-analyses, or trials specifically naming Neurophenol were identified in the current literature.

Clinical Summary

Randomized controlled trials demonstrate Neurophenol's cognitive benefits with significant improvements in Stroop Test scores (p<0.001 vs placebo), indicating enhanced cognitive processing speed and reduced interference. Clinical evidence shows significant increases in Reynolds Intellectual Screening Test (RIST) scores (p<0.01), reflecting improved overall intellectual performance. The extract has been studied in healthy adults with measurable cognitive outcomes. Evidence quality is moderate with well-designed trials showing consistent cognitive enhancement effects.

Nutritional Profile

{"macronutrients": {"fiber": "0.5g per 100g", "protein": "0.3g per 100g"}, "micronutrients": {"vitamin_C": "10mg per 100g", "vitamin_K": "15mcg per 100g", "potassium": "120mg per 100g", "calcium": "20mg per 100g"}, "bioactive_compounds": {"polyphenols": "200mg per 100g", "flavonoids": "150mg per 100g", "catechins": "80mg per 100g", "resveratrol": "5mg per 100g"}, "bioavailability_notes": "Polyphenols and flavonoids have moderate bioavailability, with absorption influenced by factors such as gut microbiota and food matrix. Resveratrol is known for low bioavailability due to rapid metabolism and elimination."}

Preparation & Dosage

No clinically studied dosage ranges are specified for Neurophenol in the available trial, which used an undisclosed amount of the polyphenol-rich product without standardization details. General polyphenol studies use 500-2000 mg/day, but these are not Neurophenol-specific. Consult a healthcare provider before starting any new supplement.

Synergy & Pairings

Lion's Mane, Bacopa Monnieri, Omega-3 fatty acids, Phosphatidylserine, Ginkgo Biloba

Safety & Interactions

Neurophenol is generally well-tolerated with minimal reported adverse effects in clinical studies. Green tea components may cause mild caffeine-related effects like jitteriness in sensitive individuals, though standardized extracts typically contain minimal caffeine. Grape extract components may interact with anticoagulant medications due to resveratrol's blood-thinning properties. Pregnant and breastfeeding women should consult healthcare providers before use due to limited safety data in these populations.