Manganese Bisglycinate

Manganese bisglycinate is a chelated form of manganese bound to two glycine amino acids for enhanced absorption. It functions as a cofactor for superoxide dismutase and enzymes involved in bone matrix formation and glucose metabolism.

Origin & History

Manganese bisglycinate is a chelated form of manganese, where manganese is bound to the amino acid glycine. This form is synthesized to enhance the bioavailability and absorption of manganese, making it an effective supplement for supporting bone and connective tissue health.

Historical & Cultural Context

Manganese has been recognized for its role in bone health since the 20th century. The chelated form, bisglycinate, was developed to improve absorption and reduce side effects.

Health Benefits

- Supports bone health by aiding in the formation of connective tissue, crucial for maintaining strong bones and joints. It enhances calcium absorption. - Acts as an antioxidant, protecting cells from free radical damage, which can slow down the aging process. - Supports carbohydrate metabolism, helping to regulate blood sugar levels and prevent spikes. - Enhances wound healing by promoting collagen formation, essential for skin repair and regeneration. - Supports brain health by participating in neurotransmitter synthesis, which can improve cognitive function and mood. - May reduce the risk of osteoporosis by improving bone mineral density, particularly in postmenopausal women. - Supports reproductive health by influencing hormone synthesis, crucial for fertility and sexual health.

How It Works

Manganese bisglycinate releases manganese ions that activate manganese superoxide dismutase (MnSOD) in mitochondria, neutralizing superoxide radicals. The mineral serves as a cofactor for glycosyltransferases in cartilage synthesis and pyruvate carboxylase in gluconeogenesis. The glycine chelation protects manganese from binding with fiber and phytates, improving intestinal absorption through amino acid transporters.

Scientific Research

Emerging research, including some human trials, suggests manganese bisglycinate's role in supporting bone health and antioxidant protection. More studies are needed to confirm its cognitive benefits.

Clinical Summary

Limited clinical trials exist specifically for manganese bisglycinate, though studies on manganese supplementation show modest benefits. A 12-week study of 334 postmenopausal women found 5mg daily manganese (with other minerals) improved bone mineral density by 1.5%. Absorption studies indicate chelated forms like bisglycinate achieve 3-5 times higher bioavailability than manganese sulfate. Most evidence comes from observational studies linking adequate manganese intake to reduced osteoporosis risk.

Nutritional Profile

- Provides manganese, an essential trace mineral for enzyme function. - Highly bioavailable form, ensuring effective absorption. - Contains glycine, which aids in reducing gastrointestinal side effects.

Preparation & Dosage

Typical dosage ranges from 1 mg to 5 mg per day. Consult a healthcare provider before use.

Synergy & Pairings

Calcium,Vitamin D,Magnesium

Safety & Interactions

Manganese bisglycinate is generally well-tolerated at doses under 10mg daily, with lower toxicity risk than inorganic forms. Excessive intake above 20mg daily may cause neurological symptoms including tremors and cognitive impairment. It may reduce absorption of iron and calcium when taken simultaneously, requiring separated dosing. Individuals with liver disease should avoid supplementation as manganese accumulates in liver tissue.