Lactobacillus reuteri DSM 17938

Lactobacillus reuteri DSM 17938 is a clinically studied probiotic strain that produces reuterin, an antimicrobial compound that helps balance gut microbiota. This strain modulates immune function through toll-like receptor signaling and supports digestive health by enhancing intestinal barrier integrity.

Origin & History

Lactobacillus reuteri DSM 17938 is a probiotic strain derived from the human gut microbiota. It is cultured through fermentation and is used in dietary supplements and functional foods.

Historical & Cultural Context

Discovered in the late 20th century, Lactobacillus reuteri DSM 17938 is a well-researched probiotic strain used in supplements and functional foods.

Health Benefits

- Supports digestive health by balancing the gut microbiota, which is crucial for nutrient absorption and overall well-being. - Enhances immune function, reducing the risk of infections by increasing the production of protective antibodies. - Promotes mental well-being by influencing the gut-brain axis, potentially alleviating anxiety and depression. - Aids in weight management by regulating fat storage and energy expenditure, supporting a healthy body weight. - Improves skin health by reducing systemic inflammation, which can alleviate conditions like acne and eczema. - Supports cardiovascular health by reducing cholesterol levels, lowering the risk of heart disease. - Enhances energy metabolism by breaking down complex carbohydrates, improving energy levels and endurance.

How It Works

Lactobacillus reuteri DSM 17938 produces reuterin (3-hydroxypropionaldehyde) from glycerol, which exhibits broad-spectrum antimicrobial activity against pathogenic bacteria while preserving beneficial microbes. The strain activates toll-like receptors (TLR2/TLR4) on intestinal epithelial cells, triggering anti-inflammatory cytokine production including IL-10. It also strengthens tight junction proteins like claudin-1 and occludin, improving intestinal barrier function and reducing inflammatory responses.

Scientific Research

Lactobacillus reuteri DSM 17938 has been studied in multiple RCTs, showing efficacy in supporting digestive and immune health. Meta-analyses confirm its benefits in various health conditions.

Clinical Summary

Multiple randomized controlled trials have demonstrated the efficacy of L. reuteri DSM 17938, particularly in pediatric populations. Studies with 50-400 participants show significant reduction in infantile colic crying time by 50-80% within 21 days of supplementation. Adult trials (n=100-200) demonstrate improved digestive symptoms and reduced inflammatory markers after 4-8 weeks of daily administration. The evidence is strongest for gastrointestinal applications, with emerging research on immune and neurological benefits showing promising but preliminary results.

Nutritional Profile

- Contains live probiotic cultures. - Produces lactic acid, supporting gut health. - Rich in bioactive compounds that modulate the immune system.

Preparation & Dosage

Typical dosage ranges from 1 to 10 billion CFU per day. Consult a healthcare provider before use.

Synergy & Pairings

Prebiotic Fiber,Omega-3 Fatty Acids,Vitamin D

Safety & Interactions

Lactobacillus reuteri DSM 17938 is generally well-tolerated with minimal reported adverse effects, primarily mild digestive symptoms during initial use. No significant drug interactions have been documented, though individuals taking immunosuppressive medications should consult healthcare providers before use. The strain is contraindicated in severely immunocompromised patients and those with central venous catheters due to rare risk of bacteremia. Safety during pregnancy and lactation appears favorable based on limited studies, but more research is needed for definitive recommendations.