Lactobacillus johnsonii No.1088

Lactobacillus johnsonii No.1088 is a probiotic strain that produces bacteriocins and short-chain fatty acids to modulate gut microbiota composition. This strain enhances intestinal barrier function and regulates immune responses through Toll-like receptor pathways.

Origin & History

Lactobacillus johnsonii No.1088 is a probiotic strain known for its potential gut health and immune support benefits. It is commonly found in the human gut and some fermented foods.

Historical & Cultural Context

Probiotics like Lactobacillus johnsonii have been used for centuries in fermented foods, valued for their health-promoting properties.

Health Benefits

- Supports digestive health by promoting a balanced gut microbiome, which enhances nutrient absorption and reduces digestive discomfort. - Enhances immune function, potentially reducing the incidence of respiratory infections by 30%. - Reduces allergy symptoms by modulating immune responses, which can decrease the severity of allergic reactions. - Supports skin health by improving the gut-skin axis, potentially reducing acne and dermatitis. - Promotes mental well-being by influencing the production of neurotransmitters, which can improve mood and reduce anxiety. - Aids in the synthesis of essential vitamins, such as B12 and folate, contributing to overall health. - Supports cardiovascular health by lowering cholesterol levels, promoting a healthier heart.

How It Works

Lactobacillus johnsonii No.1088 produces antimicrobial compounds including bacteriocins and lactic acid that inhibit pathogenic bacteria growth. The strain generates short-chain fatty acids like butyrate that strengthen intestinal epithelial tight junctions and activate regulatory T-cells. It modulates immune function by binding to dendritic cells and influencing cytokine production through Toll-like receptor 2 and 4 signaling pathways.

Scientific Research

Lactobacillus johnsonii No.1088 has been shown to support gut health and enhance immune function, with studies highlighting its role in improving symptoms of IBS and preventing infections.

Clinical Summary

Human clinical trials demonstrate that Lactobacillus johnsonii No.1088 supplementation reduces respiratory infection incidence by approximately 30% in healthy adults. Studies with 200-400 participants show significant improvements in digestive comfort and stool consistency within 4-6 weeks of daily supplementation. Preliminary research indicates potential benefits for allergic rhinitis symptoms, though larger controlled trials are needed to confirm these effects. Most clinical evidence comes from short-term studies lasting 8-12 weeks.

Nutritional Profile

- Available in probiotic supplements and some fermented foods. - Contains live bacteria beneficial for gut and immune health. - Often combined with other probiotics for enhanced effects.

Preparation & Dosage

Commonly consumed in doses of 1-10 billion CFU per day. Consult a healthcare provider before use.

Synergy & Pairings

Bifidobacterium, Prebiotics, Fermented foods, Gut microbiota, Immune support

Safety & Interactions

Lactobacillus johnsonii No.1088 is generally well-tolerated with mild gastrointestinal symptoms like bloating or gas occurring in less than 5% of users during the first week. No significant drug interactions have been reported, though individuals taking immunosuppressive medications should consult healthcare providers before use. The strain is contraindicated in severely immunocompromised patients or those with central venous catheters due to rare bacteremia risk. Safety during pregnancy and lactation has not been established through clinical trials.