Lactobacillus crispatus CTV-05
Lactobacillus crispatus CTV-05 is a clinically studied probiotic strain that produces lactic acid and hydrogen peroxide to maintain vaginal pH below 4.5. This strain specifically colonizes the vaginal epithelium to prevent pathogenic bacteria and yeast overgrowth.
Origin & History
Lactobacillus crispatus CTV-05 is a probiotic strain found in the female reproductive tract. It is known for its role in maintaining vaginal health and preventing infections.
Historical & Cultural Context
Lactobacillus crispatus has been a focus of research for its role in women's health. It is increasingly used in probiotic supplements targeting vaginal health.
Health Benefits
- Supports vaginal health by maintaining a healthy pH balance, reducing the risk of infections. This promotes a comfortable and balanced intimate environment. - Helps prevent bacterial vaginosis and yeast infections by inhibiting pathogen growth. This ensures long-term vaginal health and comfort. - Enhances immune function by increasing mucosal immunity in the vaginal tract. This strengthens the body's natural defenses against infections. - Promotes urinary tract health by preventing the adhesion of harmful bacteria. This reduces the risk of urinary tract infections. - Supports reproductive health by maintaining a balanced microbiome. This can improve fertility and overall reproductive wellness. - Reduces inflammation by modulating local immune responses. This alleviates symptoms of irritation and discomfort. - Enhances gut health by contributing to a diverse and balanced microbiome. This supports overall digestive and immune function.
How It Works
Lactobacillus crispatus CTV-05 produces lactic acid and hydrogen peroxide, creating an acidic environment (pH 3.8-4.2) that inhibits pathogenic bacteria like Gardnerella vaginalis and Candida albicans. The strain adheres to vaginal epithelial cells through specific adhesins, competing for binding sites and nutrients. It also stimulates local immune responses by modulating cytokine production and enhancing mucosal barrier function.
Scientific Research
Research indicates Lactobacillus crispatus CTV-05 can help maintain vaginal health and prevent infections. Clinical trials support its role in reducing the risk of bacterial vaginosis.
Clinical Summary
Clinical trials involving 228 women with recurrent bacterial vaginosis showed CTV-05 achieved 87% colonization rates when administered as vaginal suppositories. A randomized controlled study of 100 women demonstrated 71% reduction in BV recurrence over 12 weeks compared to placebo. Phase II trials reported significant improvements in Nugent scores from 7.2 to 3.1 after 5-day treatment cycles. Evidence quality is moderate with most studies being small-scale pilot trials requiring larger confirmatory studies.
Nutritional Profile
- Contains beneficial vaginal bacteria. - Supports reproductive health. - Enhances immune function in the reproductive tract.
Preparation & Dosage
Recommended dosage is 1-10 billion CFUs per day. Consult a healthcare provider before use.
Synergy & Pairings
Cranberry extract, Vitamin C, Lactobacillus rhamnosus
Safety & Interactions
Lactobacillus crispatus CTV-05 is generally well-tolerated with minimal reported adverse effects in clinical trials. Mild vaginal discharge or temporary irritation may occur during initial colonization in sensitive individuals. No significant drug interactions have been documented, though concurrent antibiotic use may reduce probiotic effectiveness. Safety during pregnancy and breastfeeding has not been established through controlled studies, warranting caution in these populations.