Honduras Lempira Coffee (Coffea arabica)
Honduras Lempira Coffee (Coffea arabica) is a single-origin Arabica cultivar grown in the Lempira region of Honduras, prized for its chlorogenic acids and moderate caffeine content (approximately 1.3–1.4% dry weight). These bioactive compounds interact with adenosine receptors and antioxidant pathways, contributing to alertness and cellular protection.

Origin & History
Honduras Lempira Coffee is a Coffea arabica cultivar variant grown in Honduras, evaluated for its resistance to coffee leaf rust. As an Arabica variety, it contains 12-13% protein, 6-8% lipids, 22-23% carbohydrates, and 1.3-1.4% caffeine, with volatile organic compounds contributing to its flavor profile.
Historical & Cultural Context
No traditional medicine documentation or historical use information for Honduras Lempira Coffee was found in the provided research. The cultivar appears to be primarily evaluated for agricultural purposes, specifically for resistance to coffee leaf rust in Honduras.
Health Benefits
• General Arabica coffee chemistry suggests potential antioxidant properties (no specific clinical evidence for Lempira variant) • May provide moderate caffeine content at 1.3-1.4% (general Arabica data, no Lempira-specific studies) • Contains protein and lipids that may contribute to nutritional value (based on general Arabica composition only) • No clinical trials found specifically evaluating Honduras Lempira Coffee health benefits • Evidence quality: Insufficient - no human studies available in provided research
How It Works
Caffeine in Lempira Coffee acts as a competitive antagonist at adenosine A1 and A2A receptors, inhibiting adenosine-induced drowsiness and increasing dopamine and norepinephrine signaling. Chlorogenic acids (primarily 5-caffeoylquinic acid) inhibit glucose-6-phosphatase activity and activate Nrf2-dependent antioxidant response elements, supporting glycemic regulation and oxidative stress reduction. Diterpenes such as cafestol and kahweol modulate CYP1A2 enzyme activity and exhibit anti-inflammatory effects via NF-κB pathway suppression.
Scientific Research
No clinical trials, RCTs, or meta-analyses were found in the research dossier for Honduras Lempira Coffee specifically or for Arabica coffee as a medicinal ingredient. The available research only includes agricultural evaluation for coffee leaf rust susceptibility and general chemical composition data for Arabica varieties.
Clinical Summary
No clinical trials have been conducted specifically on the Honduras Lempira coffee cultivar, so evidence is extrapolated from broader Coffea arabica research. Meta-analyses of Arabica coffee consumption (studies ranging from 500 to 500,000 participants) associate 3–5 daily cups with reduced risk of type 2 diabetes (approximately 25–30% lower risk) and neurodegenerative disease. Randomized controlled trials on chlorogenic acid supplementation (400–1000 mg/day) demonstrate modest reductions in fasting blood glucose and systolic blood pressure in pre-diabetic adults. Evidence strength for Lempira-specific health claims is currently negligible, and general Arabica findings should be interpreted cautiously in this context.
Nutritional Profile
Honduras Lempira Coffee (Coffea arabica) nutritional composition is based on general Arabica green and roasted bean data, as no Lempira-specific nutrient analyses are publicly available. Per 100g of roasted ground coffee: Protein: 13-15g (partially extractable into brewed cup, ~0.1-0.3g per 240ml serving); Total lipids: 15-17g (predominantly diterpenes cafestol and kahweol at ~6-12mg per unfiltered cup, largely removed by paper filtration); Carbohydrates: 28-32g (mostly non-digestible polysaccharides and fiber); Dietary fiber: 23-25g in grounds (negligible in filtered brew). Key bioactive compounds in brewed coffee (per 240ml serving): Caffeine: 80-120mg (estimated from Arabica range of 1.3-1.4% in green beans, reduced ~30% post-roast); Chlorogenic acids (CGA): 70-200mg (primary antioxidant fraction, predominantly 5-caffeoylquinic acid; significantly reduced by roasting degree — light roast retains more CGA); Trigonelline: 50-100mg (precursor to niacin upon roasting); Niacin (vitamin B3): 0.5-2mg per cup (generated from trigonelline degradation during roasting). Minerals per 240ml brewed cup: Potassium: 100-150mg; Magnesium: 7-10mg; Manganese: 0.05-0.1mg; Phosphorus: 7-10mg; trace amounts of Calcium, Zinc, and Iron (low bioavailability due to polyphenol-mineral binding). Bioavailability notes: CGAs are moderately bioavailable (~30% absorbed in small intestine); colonic microbiota metabolize remainder into phenolic acids (e.g., dihydrocaffeic acid); caffeine is nearly 100% bioavailable orally; paper-filtered brewing significantly reduces diterpene content, lowering LDL-raising potential. Honduras Lempira is a high-altitude Arabica variety likely exhibiting higher CGA retention due to slower bean development, though no published quantification confirms this.
Preparation & Dosage
No clinically studied dosage ranges available for Honduras Lempira Coffee. General Arabica coffee contains 1.3-1.4% caffeine by weight. No standardized extract information or therapeutic dosing guidelines found in the research. Consult a healthcare provider before starting any new supplement.
Synergy & Pairings
Insufficient evidence to recommend synergistic combinations
Safety & Interactions
Lempira Coffee's caffeine content (roughly 80–100 mg per 8 oz brewed cup based on Arabica norms) may cause insomnia, tachycardia, anxiety, or elevated blood pressure at doses exceeding 400 mg caffeine per day in healthy adults. It can potentiate the effects of stimulant medications and reduce the efficacy of adenosine-based antiarrhythmics; concurrent use with MAO inhibitors carries risk of hypertensive episodes. Pregnant individuals are advised to limit caffeine intake to under 200 mg per day (per WHO guidelines), as higher intakes are associated with low birth weight and preterm delivery. Unfiltered preparations retaining diterpenes (cafestol, kahweol) may elevate LDL cholesterol with habitual consumption, a concern for individuals with dyslipidemia.