Folate (Quatrefolic)
Quatrefolic is a patented form of 5-methyltetrahydrofolate, the bioactive form of folate that bypasses genetic variations in folate metabolism. It directly supports methylation reactions, DNA synthesis, and cardiovascular health through homocysteine reduction.
Origin & History
Quatrefolic is a patented form of 5-MTHF, the active form of folate. It is designed to enhance stability and bioavailability in the body.
Historical & Cultural Context
Quatrefolic represents a modern advancement in folate supplementation, providing a more stable and effective form for individuals with absorption challenges.
Health Benefits
- Provides a stable, bioactive form of folate for immediate use, enhancing nutrient absorption and effectiveness. This supports overall health and vitality. - Supports cardiovascular health by reducing homocysteine levels, lowering heart disease risk by 25%. This promotes a healthy heart and circulatory system. - Enhances neurotransmitter synthesis, improving mood and cognitive function. This can lead to better mental health and emotional stability. - Boosts energy levels by aiding in red blood cell production. This helps combat fatigue and improve overall vitality. - Supports immune function by enhancing white blood cell production. This strengthens the body's defense against infections. - Aids in DNA synthesis and repair, maintaining genetic integrity and cellular health. This is crucial for long-term health and disease prevention. - Supports healthy fetal development, reducing the risk of neural tube defects. This is essential for expectant mothers and their babies.
How It Works
Quatrefolic delivers 5-methyltetrahydrofolate directly to cells, bypassing the MTHFR enzyme conversion required for folic acid. It serves as a methyl donor in the methylation cycle, supporting methionine synthase activity and converting homocysteine to methionine. This enhanced bioavailability ensures optimal folate status regardless of genetic polymorphisms in folate metabolism.
Scientific Research
Quatrefolic has been shown to be more stable and bioavailable than other forms of folate. Research supports its role in cardiovascular and mental health.
Clinical Summary
Clinical studies demonstrate Quatrefolic's superior bioavailability compared to folic acid, with plasma folate levels increasing more effectively. Research shows consistent homocysteine reduction of 20-25% in supplementation studies with 400-800 mcg daily doses. Multiple trials confirm improved folate status in individuals with MTHFR genetic variants who poorly convert synthetic folic acid. Evidence supports cardiovascular benefits through sustained homocysteine lowering over 8-12 week intervention periods.
Nutritional Profile
- Patented form of active folate with enhanced stability. - High bioavailability for effective absorption. - Supports critical biochemical processes.
Preparation & Dosage
Recommended dosage is 400 mcg to 800 mcg daily. Consult a healthcare provider before use.
Synergy & Pairings
Vitamin B6, Vitamin B12, Omega-3, Magnesium, Probiotics
Safety & Interactions
Quatrefolic is generally well-tolerated with minimal side effects at recommended doses of 400-1000 mcg daily. It may interact with methotrexate and anticonvulsants by affecting folate metabolism pathways. High doses above 1000 mcg should be monitored as they may mask vitamin B12 deficiency symptoms. Pregnant and breastfeeding women should consult healthcare providers, though folate supplementation is typically recommended during pregnancy.