Cold-Pressed Almond Oil (Prunus dulcis)
Cold-pressed almond oil contains high concentrations of vitamin E, oleic acid, and linoleic acid that provide skin barrier protection and cardiovascular support. Clinical studies demonstrate significant reductions in pressure injuries and cholesterol levels through anti-inflammatory and moisturizing mechanisms.

Origin & History
Cold-pressed almond oil is extracted from sweet almond kernels (Prunus dulcis) native to the Middle East and South Asia, now widely cultivated in California, Europe, and the Mediterranean. The oil is mechanically extracted at temperatures below 49°C to preserve heat-sensitive compounds like tocopherols, avoiding chemical solvents.
Historical & Cultural Context
Sweet almond oil has been used for centuries in Unani, Ayurveda, and Middle Eastern folk medicine for treating dry skin, atopic dermatitis, and scalp conditions. Persian and Islamic traditions particularly valued it for moisturizing and antiaging properties.
Health Benefits
• Reduces pressure injury incidence by 78% in ICU patients compared to control (RCT, n=108, moderate evidence) • Lowers total cholesterol and LDL levels in dyslipidemic patients (preliminary clinical evidence) • Demonstrates antiangiogenic properties with IC50 of 12.90 µg/mL in ex vivo studies (preliminary evidence) • May reduce wrinkle severity when almonds consumed orally for 16 weeks (RCT, n=28, moderate evidence) • Traditional use for skin moisturizing and dry skin conditions (historical evidence only)
How It Works
Cold-pressed almond oil's vitamin E content provides antioxidant protection by scavenging free radicals and stabilizing cell membranes. The oleic acid (60-70%) and linoleic acid (20-30%) enhance skin barrier function by improving lipid bilayer integrity and reducing transepidermal water loss. Antiangiogenic properties appear to work through inhibition of endothelial cell proliferation pathways.
Scientific Research
A single-blind RCT (n=108, PMID: 32379165) showed topical almond oil reduced pressure injuries to 5.6% versus 25.1% in controls. Limited human trials exist, with one dyslipidemic study (PMID: 30670262) and an almond consumption trial (NCT02954315) showing skin benefits, though most evidence remains ex vivo or traditional.
Clinical Summary
A randomized controlled trial with 108 ICU patients showed cold-pressed almond oil reduced pressure injury incidence by 78% compared to control groups. Preliminary clinical studies in dyslipidemic patients demonstrated reductions in total cholesterol and LDL levels, though sample sizes and study duration were limited. Ex vivo studies revealed antiangiogenic activity with an IC50 of 12.90 µg/mL, indicating moderate potency. Current clinical evidence is promising but requires larger, longer-term trials for definitive therapeutic recommendations.
Nutritional Profile
Cold-pressed almond oil (Prunus dulcis) is composed of approximately 99.9% fat with negligible protein, carbohydrate, and fiber content. **Fatty Acid Profile (per 100 mL):** Oleic acid (monounsaturated, C18:1) ~62–78% of total fatty acids; Linoleic acid (polyunsaturated, C18:2 omega-6) ~12–28%; Palmitic acid (saturated, C16:0) ~5–7%; Stearic acid (saturated, C18:0) ~1–2%; Palmitoleic acid (C16:1) ~0.3–0.7%. Total MUFA content ~68–72 g/100 mL; total PUFA ~17–25 g/100 mL; total SFA ~7–9 g/100 mL. Energy density ~3,700 kJ (884 kcal) per 100 mL. **Vitamin E (tocopherols):** α-tocopherol ~35–55 mg/100 mL (primary form, providing ~250–370% of adult RDA per 100 mL); γ-tocopherol ~1–5 mg/100 mL; δ-tocopherol trace amounts. Cold-pressing preserves tocopherol content significantly better than refined processing (~20–40% higher retention). **Phytosterols:** Total phytosterols ~200–350 mg/100 mL, predominantly β-sitosterol (~130–220 mg), campesterol (~15–30 mg), and stigmasterol (~5–15 mg); these compete with cholesterol for intestinal absorption, contributing to LDL-lowering effects; bioavailability of phytosterols from oil matrix is moderate (~2–5% absorption). **Squalene:** ~20–70 mg/100 mL; a triterpene hydrocarbon with antioxidant and skin-emollient properties. **Polyphenolic compounds:** Low but detectable levels in cold-pressed form, including flavonoids (kaempferol, quercetin glycosides at trace levels ~0.5–3 mg/100 mL) and phenolic acids (caffeic acid, vanillic acid, p-coumaric acid in trace quantities); significantly reduced compared to whole almonds due to exclusion of skin/meal during pressing. **Minerals:** Trace amounts only — potassium, phosphorus, calcium, and magnesium each typically <2 mg/100 mL (nutritionally negligible). **Bioactive lipid-soluble compounds:** Amygdalin is absent or below detection limits in sweet almond (P. dulcis var. dulcis) oil; bitter almond variety (var. amara) may contain trace cyanogenic glycosides but is not used for food-grade oil. **Bioavailability notes:** Fat-soluble vitamins (especially α-tocopherol) are highly bioavailable when consumed as part of the oil matrix (~60–80% absorption). The predominantly oleic acid matrix enhances absorption of co-consumed fat-soluble nutrients. Phytosterol bioavailability is inherently low but functionally relevant at the intestinal level for cholesterol displacement. Cold-pressing at temperatures typically <40–50°C preserves thermolabile compounds (tocopherols, polyphenols, squalene) compared to solvent-extracted or refined almond oils, where losses of 30–60% of tocopherols and near-complete loss of polyphenols are reported. Omega-6 to omega-3 ratio is very high (linoleic acid dominant with negligible α-linolenic acid <0.1%), which should be considered in the context of overall dietary fatty acid balance.
Preparation & Dosage
Topical: Daily application (volume unspecified) for pressure injury prevention. Ex vivo studies used 6.25-200 µg/mL concentrations. No standardized oral dosing established in human trials. Consult a healthcare provider before starting any new supplement.
Synergy & Pairings
Vitamin E, Omega-3 fatty acids, Aspirin (ex vivo synergy only), Collagen, Hyaluronic acid
Safety & Interactions
Cold-pressed almond oil is generally well-tolerated topically and orally in food amounts. Individuals with tree nut allergies should avoid use due to potential cross-reactivity with almond proteins. No significant drug interactions are documented, but theoretical concerns exist with anticoagulant medications due to vitamin E content. Pregnancy and breastfeeding safety data is limited, though topical use appears safe in normal amounts.