Bacillus indicus HU36

Bacillus indicus HU36 is a spore-forming soil-based probiotic that produces powerful antioxidants including CoQ10, alpha-tocopherol, and beta-carotene directly in the gut. This strain supports digestive health, enhances immune function, and reduces oxidative stress through its unique ability to synthesize these protective compounds in vivo.

Origin & History

Bacillus indicus HU36 is a soil-based probiotic strain isolated from natural soil environments. It is produced through fermentation and is unique for its ability to produce carotenoids.

Historical & Cultural Context

Bacillus indicus has been studied for its unique ability to produce carotenoids, contributing to its potential health benefits.

Health Benefits

- Supports gut health by promoting beneficial bacteria, enhancing nutrient absorption. - Enhances immune function through antioxidant production, reducing oxidative stress. - Reduces inflammation by modulating cytokine levels, promoting overall wellness. - Improves skin health by reducing systemic inflammation, leading to clearer skin. - Aids in weight management by influencing hormones that regulate appetite. - Boosts mood by producing neurotransmitters like serotonin, enhancing mental well-being. - Supports respiratory health by reducing inflammation, promoting easier breathing.

How It Works

Bacillus indicus HU36 produces coenzyme Q10, alpha-tocopherol, and beta-carotene through its mevalonate pathway and carotenoid biosynthesis systems. These antioxidants neutralize reactive oxygen species and support mitochondrial function while the probiotic modulates gut microbiota composition. The strain also influences cytokine production, particularly reducing pro-inflammatory IL-6 and TNF-alpha while promoting beneficial short-chain fatty acid production.

Scientific Research

Emerging studies suggest its role in reducing oxidative stress and supporting immune function. In vitro studies highlight its antioxidant properties.

Clinical Summary

Clinical studies on Bacillus indicus HU36 are limited, with most evidence coming from in vitro studies demonstrating antioxidant production capabilities. Small pilot studies suggest improvements in gut microbiome diversity and reduced oxidative stress markers, but large-scale randomized controlled trials are lacking. The strain's unique antioxidant-producing ability has been confirmed through laboratory analysis, showing measurable CoQ10 and carotenoid synthesis. More human clinical data is needed to establish definitive therapeutic benefits and optimal dosing protocols.

Nutritional Profile

- Produces carotenoids, which are powerful antioxidants. - Contains spores that ensure survival through the digestive tract. - Supports the production of beneficial metabolites.

Preparation & Dosage

Typically taken in doses of 1-5 billion CFUs per day. Available in capsule or powder form. Consult a healthcare provider before use.

Synergy & Pairings

Vitamin E, Selenium, Beta-Carotene

Safety & Interactions

Bacillus indicus HU36 is generally well-tolerated with minimal reported side effects in healthy adults. Mild digestive symptoms like bloating or gas may occur during initial supplementation as gut microbiota adjusts. No significant drug interactions have been documented, though individuals on immunosuppressive medications should consult healthcare providers before use. Safety during pregnancy and breastfeeding has not been established, so use should be avoided during these periods.